Wang R - Search Results

1

Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9.

Appleby TC, Greenstein AE, Hung M, Liclican A, Velasquez M, Villaseñor AG, Wang R, Wong MH, Liu X, Papalia GA, Schultz BE, Sakowicz R, Smith V, Kwon HJ. Appleby TC, et al. Among authors: wang r. J Biol Chem. 2017 Apr 21;292(16):6810-6820. doi: 10.1074/jbc.M116.760579. Epub 2017 Feb 24. J Biol Chem. 2017. PMID: 28235803 Free PMC article.

2

Crystal structures of HIV-1 reverse transcriptase with etravirine (TMC125) and rilpivirine (TMC278): implications for drug design.

Lansdon EB, Brendza KM, Hung M, Wang R, Mukund S, Jin D, Birkus G, Kutty N, Liu X. Lansdon EB, et al. Among authors: wang r. J Med Chem. 2010 May 27;53(10):4295-9. doi: 10.1021/jm1002233. J Med Chem. 2010. PMID: 20438081

3

The macroscopic rate of nucleic acid translocation by hepatitis C virus helicase NS3h is dependent on both sugar and base moieties.

Khaki AR, Field C, Malik S, Niedziela-Majka A, Leavitt SA, Wang R, Hung M, Sakowicz R, Brendza KM, Fischer CJ. Khaki AR, et al. Among authors: wang r. J Mol Biol. 2010 Jul 16;400(3):354-78. doi: 10.1016/j.jmb.2010.04.065. Epub 2010 May 6. J Mol Biol. 2010. PMID: 20451531 Free PMC article.

4

Visualizing ATP-dependent RNA translocation by the NS3 helicase from HCV.

Appleby TC, Anderson R, Fedorova O, Pyle AM, Wang R, Liu X, Brendza KM, Somoza JR. Appleby TC, et al. Among authors: wang r. J Mol Biol. 2011 Feb 4;405(5):1139-53. doi: 10.1016/j.jmb.2010.11.034. Epub 2010 Dec 9. J Mol Biol. 2011. PMID: 21145896 Free PMC article.

5

Preparation of HCV NS3 and NS5B proteins to support small-molecule drug discovery.

Hung M, Wang R, Liu X. Hung M, et al. Among authors: wang r. Curr Protoc Pharmacol. 2011 Sep;Chapter 13:Unit13B.6. doi: 10.1002/0471141755.ph13b06s54. Curr Protoc Pharmacol. 2011. PMID: 21898331

6

Binding kinetics, potency, and selectivity of the hepatitis C virus NS3 protease inhibitors GS-9256 and vedroprevir.

Barauskas O, Corsa AC, Wang R, Hluhanich S, Jin D, Hung M, Yang H, Delaney WE 4th, Schultz BE. Barauskas O, et al. Among authors: wang r. Biochim Biophys Acta. 2014 Dec;1840(12):3292-8. doi: 10.1016/j.bbagen.2014.08.002. Epub 2014 Aug 17. Biochim Biophys Acta. 2014. PMID: 25139683

7

Structural, biochemical, and biophysical characterization of idelalisib binding to phosphoinositide 3-kinase δ.

Somoza JR, Koditek D, Villaseñor AG, Novikov N, Wong MH, Liclican A, Xing W, Lagpacan L, Wang R, Schultz BE, Papalia GA, Samuel D, Lad L, McGrath ME. Somoza JR, et al. Among authors: wang r. J Biol Chem. 2015 Mar 27;290(13):8439-46. doi: 10.1074/jbc.M114.634683. Epub 2015 Jan 28. J Biol Chem. 2015. PMID: 25631052 Free PMC article.

8

Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer.

Marshall DC, Lyman SK, McCauley S, Kovalenko M, Spangler R, Liu C, Lee M, O'Sullivan C, Barry-Hamilton V, Ghermazien H, Mikels-Vigdal A, Garcia CA, Jorgensen B, Velayo AC, Wang R, Adamkewicz JI, Smith V. Marshall DC, et al. Among authors: wang r. PLoS One. 2015 May 11;10(5):e0127063. doi: 10.1371/journal.pone.0127063. eCollection 2015. PLoS One. 2015. PMID: 25961845 Free PMC article.

9

Protein Footprinting and X-ray Crystallography Reveal the Interaction of PD-L1 and a Macrocyclic Peptide.

Niu B, Appleby TC, Wang R, Morar M, Voight J, Villaseñor AG, Clancy S, Wise S, Belzile JP, Papalia G, Wong M, Brendza KM, Lad L, Gross ML. Niu B, et al. Among authors: wang r. Biochemistry. 2020 Feb 4;59(4):541-551. doi: 10.1021/acs.biochem.9b00822. Epub 2019 Dec 31. Biochemistry. 2020. PMID: 31841311 Free PMC article.

10

Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability.

Mulato A, Lansdon E, Aoyama R, Voigt J, Lee M, Liclican A, Lee G, Singer E, Stafford B, Gong R, Murray B, Chan J, Lee J, Xu Y, Ahmadyar S, Gonzalez A, Cho A, Stepan GJ, Schmitz U, Schultz B, Marchand B, Brumshtein B, Wang R, Yu H, Cihlar T, Xu L, Yant SR. Mulato A, et al. Among authors: wang r. Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0137323. doi: 10.1128/aac.01373-23. Epub 2024 Feb 21. Antimicrob Agents Chemother. 2024. PMID: 38380945 Free PMC article.

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