Szewczyk JW - Search Results

1

Discovery of phenyl acetamides as potent and selective GPR119 agonists.

Zhu C, Wang L, Zhu Y, Guo ZZ, Liu P, Hu Z, Szewczyk JW, Kang L, Chicchi G, Ehrhardt A, Woods A, Seo T, Woods M, van Heek M, Dingley KH, Pang J, Salituro GM, Powell J, Terebetski JL, Hornak V, Campeau LC, Orr RK, Ujjainwalla F, Miller M, Stamford A, Wood HB, Kowalski T, Nargund RP, Edmondson SD. Zhu C, et al. Among authors: szewczyk jw. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1124-1128. doi: 10.1016/j.bmcl.2017.01.091. Epub 2017 Feb 1. Bioorg Med Chem Lett. 2017. PMID: 28185720

2

Design of potent and selective GPR119 agonists for type II diabetes.

Szewczyk JW, Acton J, Adams AD, Chicchi G, Freeman S, Howard AD, Huang Y, Li C, Meinke PT, Mosely R, Murphy E, Samuel R, Santini C, Yang M, Zhang Y, Zhao K, Wood HB. Szewczyk JW, et al. Bioorg Med Chem Lett. 2011 May 1;21(9):2665-9. doi: 10.1016/j.bmcl.2010.12.086. Epub 2010 Dec 22. Bioorg Med Chem Lett. 2011. PMID: 21273063

3

SAR studies: designing potent and selective LXR agonists.

Szewczyk JW, Huang S, Chin J, Tian J, Mitnaul L, Rosa RL, Peterson L, Sparrow CP, Adams AD. Szewczyk JW, et al. Bioorg Med Chem Lett. 2006 Jun 1;16(11):3055-60. doi: 10.1016/j.bmcl.2006.02.050. Epub 2006 Mar 10. Bioorg Med Chem Lett. 2006. PMID: 16529931

4

Optimization of 3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepines as potent, orally active CCK-A agonists.

Henke BR, Aquino CJ, Birkemo LS, Croom DK, Dougherty RW Jr, Ervin GN, Grizzle MK, Hirst GC, James MK, Johnson MF, Queen KL, Sherrill RG, Sugg EE, Suh EM, Szewczyk JW, Unwalla RJ, Yingling J, Willson TM. Henke BR, et al. Among authors: szewczyk jw. J Med Chem. 1997 Aug 15;40(17):2706-25. doi: 10.1021/jm970265x. J Med Chem. 1997. PMID: 9276016

5

Alternative heterocycles for DNA recognition: an N-methylpyrazole/N-methylpyrrole pair specifies for A.T/T.A base pairs.

Nguyen DH, Szewczyk JW, Baird EE, Dervan PB. Nguyen DH, et al. Among authors: szewczyk jw. Bioorg Med Chem. 2001 Jan;9(1):7-17. doi: 10.1016/s0968-0896(00)00219-4. Bioorg Med Chem. 2001. PMID: 11197348

6

Recognition of the DNA minor groove by pyrrole-imidazole polyamides: comparison of desmethyl- and N-methylpyrrole.

Bremer RE, Szewczyk JW, Baird EE, Dervan PB. Bremer RE, et al. Among authors: szewczyk jw. Bioorg Med Chem. 2000 Aug;8(8):1947-55. doi: 10.1016/s0968-0896(00)00145-0. Bioorg Med Chem. 2000. PMID: 11003140

7

Inhibition of major groove DNA binding bZIP proteins by positive patch polyamides.

Bremer RE, Wurtz NR, Szewczyk JW, Dervan PB. Bremer RE, et al. Among authors: szewczyk jw. Bioorg Med Chem. 2001 Aug;9(8):2093-103. doi: 10.1016/s0968-0896(01)00122-5. Bioorg Med Chem. 2001. PMID: 11504645

8

Identification of novel metabolites of pioglitazone in rat and dog.

Shen Z, Reed JR, Creighton M, Liu DQ, Tang YS, Hora DF, Feeney W, Szewczyk J, Bakhtiar R, Franklin RB, Vincent SH. Shen Z, et al. Xenobiotica. 2003 May;33(5):499-509. doi: 10.1080/0049825031000085951. Xenobiotica. 2003. PMID: 12746106

9

Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands.

White S, Szewczyk JW, Turner JM, Baird EE, Dervan PB. White S, et al. Among authors: szewczyk jw. Nature. 1998 Jan 29;391(6666):468-71. doi: 10.1038/35106. Nature. 1998. PMID: 9461213 Free article.

10

A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA.

Kielkopf CL, White S, Szewczyk JW, Turner JM, Baird EE, Dervan PB, Rees DC. Kielkopf CL, et al. Among authors: szewczyk jw. Science. 1998 Oct 2;282(5386):111-5. doi: 10.1126/science.282.5386.111. Science. 1998. PMID: 9756473

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