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Page 1
Therapeutic Strategies for Restoring Tau Homeostasis.
Young ZT, Mok SA, Gestwicki JE. Young ZT, et al. Among authors: gestwicki je. Cold Spring Harb Perspect Med. 2018 Jan 2;8(1):a024612. doi: 10.1101/cshperspect.a024612. Cold Spring Harb Perspect Med. 2018. PMID: 28159830 Free PMC article. Review.
Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels.
Miyata Y, Li X, Lee HF, Jinwal UK, Srinivasan SR, Seguin SP, Young ZT, Brodsky JL, Dickey CA, Sun D, Gestwicki JE. Miyata Y, et al. Among authors: gestwicki je. ACS Chem Neurosci. 2013 Jun 19;4(6):930-9. doi: 10.1021/cn300210g. Epub 2013 Mar 20. ACS Chem Neurosci. 2013. PMID: 23472668 Free PMC article.
Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau.
Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, Young ZT, Atkins CA, Zhang B, Lawson LY, Weeber EJ, Brodsky JL, Gestwicki JE, Dickey CA. Abisambra J, et al. Among authors: gestwicki je. Biol Psychiatry. 2013 Sep 1;74(5):367-74. doi: 10.1016/j.biopsych.2013.02.027. Epub 2013 Apr 19. Biol Psychiatry. 2013. PMID: 23607970 Free PMC article.
Hsp70-Bag3 interactions regulate cancer-related signaling networks.
Colvin TA, Gabai VL, Gong J, Calderwood SK, Li H, Gummuluru S, Matchuk ON, Smirnova SG, Orlova NV, Zamulaeva IA, Garcia-Marcos M, Li X, Young ZT, Rauch JN, Gestwicki JE, Takayama S, Sherman MY. Colvin TA, et al. Among authors: gestwicki je. Cancer Res. 2014 Sep 1;74(17):4731-40. doi: 10.1158/0008-5472.CAN-14-0747. Epub 2014 Jul 3. Cancer Res. 2014. PMID: 24994713 Free PMC article.
Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement.
Fontaine SN, Rauch JN, Nordhues BA, Assimon VA, Stothert AR, Jinwal UK, Sabbagh JJ, Chang L, Stevens SM Jr, Zuiderweg ER, Gestwicki JE, Dickey CA. Fontaine SN, et al. Among authors: gestwicki je. J Biol Chem. 2015 May 22;290(21):13115-27. doi: 10.1074/jbc.M115.637595. Epub 2015 Apr 11. J Biol Chem. 2015. PMID: 25864199 Free PMC article.
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.
Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, Verdin E, Gan L. Min SW, et al. Nat Med. 2015 Oct;21(10):1154-62. doi: 10.1038/nm.3951. Epub 2015 Sep 21. Nat Med. 2015. PMID: 26390242 Free PMC article.
Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy.
Young ZT, Rauch JN, Assimon VA, Jinwal UK, Ahn M, Li X, Dunyak BM, Ahmad A, Carlson GA, Srinivasan SR, Zuiderweg ER, Dickey CA, Gestwicki JE. Young ZT, et al. Among authors: gestwicki je. Cell Chem Biol. 2016 Aug 18;23(8):992-1001. doi: 10.1016/j.chembiol.2016.04.014. Epub 2016 Aug 4. Cell Chem Biol. 2016. PMID: 27499529 Free PMC article.
232 results