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A phase 1/2a, dose-escalation, safety, pharmacokinetic, and preliminary efficacy study of intraperitoneal administration of BC-819 (H19-DTA) in subjects with recurrent ovarian/peritoneal cancer.
Lavie O, Edelman D, Levy T, Fishman A, Hubert A, Segev Y, Raveh E, Gilon M, Hochberg A. Lavie O, et al. Among authors: hubert a. Arch Gynecol Obstet. 2017 Mar;295(3):751-761. doi: 10.1007/s00404-017-4293-0. Epub 2017 Feb 3. Arch Gynecol Obstet. 2017. PMID: 28154921 Free PMC article. Clinical Trial.
Phase 1/2a, dose-escalation, safety, pharmacokinetic and preliminary efficacy study of intratumoral administration of BC-819 in patients with unresectable pancreatic cancer.
Hanna N, Ohana P, Konikoff FM, Leichtmann G, Hubert A, Appelbaum L, Kopelman Y, Czerniak A, Hochberg A. Hanna N, et al. Among authors: hubert a. Cancer Gene Ther. 2012 Jun;19(6):374-81. doi: 10.1038/cgt.2012.10. Epub 2012 Apr 13. Cancer Gene Ther. 2012. PMID: 22498722 Clinical Trial.
Oncofetal H19 RNA promotes tumor metastasis.
Matouk IJ, Raveh E, Abu-lail R, Mezan S, Gilon M, Gershtain E, Birman T, Gallula J, Schneider T, Barkali M, Richler C, Fellig Y, Sorin V, Hubert A, Hochberg A, Czerniak A. Matouk IJ, et al. Among authors: hubert a. Biochim Biophys Acta. 2014 Jul;1843(7):1414-26. doi: 10.1016/j.bbamcr.2014.03.023. Epub 2014 Apr 2. Biochim Biophys Acta. 2014. PMID: 24703882 Free article.
Treatment inferred from mutations identified using massive parallel sequencing leads to clinical benefit in some heavily pretreated cancer patients.
Zick A, Peretz T, Lotem M, Hubert A, Katz D, Temper M, Rottenberg Y, Uziely B, Nechushtan H, Meirovitz A, Sonnenblick A, Sapir E, Edelman D, Goldberg Y, Lossos A, Rosenberg S, Fried I, Finklstein R, Pikarsky E, Goldshmidt H. Zick A, et al. Among authors: hubert a. Medicine (Baltimore). 2017 May;96(20):e6931. doi: 10.1097/MD.0000000000006931. Medicine (Baltimore). 2017. PMID: 28514312 Free PMC article.
310 results