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The Exportin-1 Inhibitor Selinexor Exerts Superior Antitumor Activity when Combined with T-Cell Checkpoint Inhibitors.
Farren MR, Hennessey RC, Shakya R, Elnaggar O, Young G, Kendra K, Landesman Y, Elloul S, Crochiere M, Klebanov B, Kashyap T, Burd CE, Lesinski GB. Farren MR, et al. Among authors: elnaggar o. Mol Cancer Ther. 2017 Mar;16(3):417-427. doi: 10.1158/1535-7163.MCT-16-0498. Epub 2017 Feb 1. Mol Cancer Ther. 2017. PMID: 28148715 Free PMC article.
Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities.
Talbert EE, Yang J, Mace TA, Farren MR, Farris AB, Young GS, Elnaggar O, Che Z, Timmers CD, Rajasekera P, Maskarinec JM, Bloomston M, Bekaii-Saab T, Guttridge DC, Lesinski GB. Talbert EE, et al. Among authors: elnaggar o. Mol Cancer Ther. 2017 Feb;16(2):344-356. doi: 10.1158/1535-7163.MCT-16-0337. Epub 2016 Nov 3. Mol Cancer Ther. 2017. PMID: 27811010 Free PMC article.
Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer.
Mace TA, Shakya R, Elnaggar O, Wilson K, Komar HM, Yang J, Pitarresi JR, Young GS, Ostrowski MC, Ludwig T, Bekaii-Saab T, Bloomston M, Lesinski GB. Mace TA, et al. Among authors: elnaggar o. Oncotarget. 2015 Dec 29;6(42):44509-22. doi: 10.18632/oncotarget.6332. Oncotarget. 2015. PMID: 26575024 Free PMC article.
Suppressive myeloid cells are expanded by biliary tract cancer-derived cytokines in vitro and associate with aggressive disease.
Ware MB, Zaidi MY, Yang J, Turgeon MK, Krasinskas A, Mace TA, Keenan K, Farren MR, Ruggieri AN, Li Y, Zhang C, Chen Z, Young GS, Elnaggar O, Che Z, Maithel SK, Bekaii-Saab T, El-Rayes B, Lesinski GB. Ware MB, et al. Among authors: elnaggar o. Br J Cancer. 2020 Oct;123(9):1377-1386. doi: 10.1038/s41416-020-1018-0. Epub 2020 Aug 4. Br J Cancer. 2020. PMID: 32747748 Free PMC article.
Bioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling.
Mace TA, King SA, Ameen Z, Elnaggar O, Young G, Riedl KM, Schwartz SJ, Clinton SK, Knobloch TJ, Weghorst CM, Lesinski GB. Mace TA, et al. Among authors: elnaggar o. Cancer Immunol Immunother. 2014 Sep;63(9):889-900. doi: 10.1007/s00262-014-1564-5. Epub 2014 Jun 4. Cancer Immunol Immunother. 2014. PMID: 24893859 Free PMC article.
16 results