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EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay.
Volpi S, Yamazaki Y, Brauer PM, van Rooijen E, Hayashida A, Slavotinek A, Sun Kuehn H, Di Rocco M, Rivolta C, Bortolomai I, Du L, Felgentreff K, Ott de Bruin L, Hayashida K, Freedman G, Marcovecchio GE, Capuder K, Rath P, Luche N, Hagedorn EJ, Buoncompagni A, Royer-Bertrand B, Giliani S, Poliani PL, Imberti L, Dobbs K, Poulain FE, Martini A, Manis J, Linhardt RJ, Bosticardo M, Rosenzweig SD, Lee H, Puck JM, Zúñiga-Pflücker JC, Zon L, Park PW, Superti-Furga A, Notarangelo LD. Volpi S, et al. Among authors: linhardt rj. J Exp Med. 2017 Mar 6;214(3):623-637. doi: 10.1084/jem.20161525. Epub 2017 Feb 1. J Exp Med. 2017. PMID: 28148688 Free PMC article.
Design of anti-inflammatory heparan sulfate to protect against acetaminophen-induced acute liver failure.
Arnold K, Xu Y, Sparkenbaugh EM, Li M, Han X, Zhang X, Xia K, Piegore M, Zhang F, Zhang X, Henderson M, Pagadala V, Su G, Tan L, Park PW, Stravitz RT, Key NS, Linhardt RJ, Pawlinski R, Xu D, Liu J. Arnold K, et al. Among authors: linhardt rj. Sci Transl Med. 2020 Mar 18;12(535):eaav8075. doi: 10.1126/scitranslmed.aav8075. Sci Transl Med. 2020. PMID: 32188725 Free PMC article.
Proteoglycans in stem cells.
Gasimli L, Linhardt RJ, Dordick JS. Gasimli L, et al. Among authors: linhardt rj. Biotechnol Appl Biochem. 2012 Mar-Apr;59(2):65-76. doi: 10.1002/bab.1002. Epub 2012 Feb 28. Biotechnol Appl Biochem. 2012. PMID: 23586787 Review.
Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.
Patel VN, Pineda DL, Berenstein E, Hauser BR, Choi S, Prochazkova M, Zheng C, Goldsmith CM, van Kuppevelt TH, Kulkarni A, Song Y, Linhardt RJ, Chibly AM, Hoffman MP. Patel VN, et al. Among authors: linhardt rj. Matrix Biol. 2021 Sep;103-104:37-57. doi: 10.1016/j.matbio.2021.10.002. Epub 2021 Oct 12. Matrix Biol. 2021. PMID: 34653670 Free PMC article.
Bioengineered heparins and heparan sulfates.
Fu L, Suflita M, Linhardt RJ. Fu L, et al. Among authors: linhardt rj. Adv Drug Deliv Rev. 2016 Feb 1;97:237-49. doi: 10.1016/j.addr.2015.11.002. Epub 2015 Nov 10. Adv Drug Deliv Rev. 2016. PMID: 26555370 Free PMC article. Review.
991 results