Sordella R - Search Results

1

TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions.

Shirole NH, Pal D, Kastenhuber ER, Senturk S, Boroda J, Pisterzi P, Miller M, Munoz G, Anderluh M, Ladanyi M, Lowe SW, Sordella R. Shirole NH, et al. Among authors: sordella r. Elife. 2017 Feb 1;6:e25532. doi: 10.7554/eLife.25532. Elife. 2017. PMID: 28145225 Free PMC article. No abstract available.

2

TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions.

Shirole NH, Pal D, Kastenhuber ER, Senturk S, Boroda J, Pisterzi P, Miller M, Munoz G, Anderluh M, Ladanyi M, Lowe SW, Sordella R. Shirole NH, et al. Among authors: sordella r. Elife. 2016 Oct 19;5:e17929. doi: 10.7554/eLife.17929. Elife. 2016. PMID: 27759562 Free PMC article.

3

The Evolution of TP53 Mutations: From Loss-of-Function to Separation-of-Function Mutants.

Miller M, Shirole N, Tian R, Pal D, Sordella R. Miller M, et al. Among authors: sordella r. J Cancer Biol Res. 2016;4(4):1091. Epub 2016 Dec 23. J Cancer Biol Res. 2016. PMID: 28191499 Free PMC article.

4

TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells.

Pal D, Pertot A, Shirole NH, Yao Z, Anaparthy N, Garvin T, Cox H, Chang K, Rollins F, Kendall J, Edwards L, Singh VA, Stone GC, Schatz MC, Hicks J, Hannon GJ, Sordella R. Pal D, et al. Among authors: sordella r. Elife. 2017 Jan 16;6:e21615. doi: 10.7554/eLife.21615. Elife. 2017. PMID: 28092266 Free PMC article.

5

An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression.

Safaric Tepes P, Pal D, Lindsted T, Ibarra I, Lujambio A, Jimenez Sabinina V, Senturk S, Miller M, Korimerla N, Huang J, Glassman L, Lee P, Zeltsman D, Hyman K, Esposito M, Hannon GJ, Sordella R. Safaric Tepes P, et al. Among authors: sordella r. Elife. 2021 Jul 13;10:e66109. doi: 10.7554/eLife.66109. Elife. 2021. PMID: 34254585 Free PMC article.

6

Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization.

Senturk S, Shirole NH, Nowak DG, Corbo V, Pal D, Vaughan A, Tuveson DA, Trotman LC, Kinney JB, Sordella R. Senturk S, et al. Among authors: sordella r. Nat Commun. 2017 Feb 22;8:14370. doi: 10.1038/ncomms14370. Nat Commun. 2017. PMID: 28224990 Free PMC article.

7

p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state.

Senturk S, Yao Z, Camiolo M, Stiles B, Rathod T, Walsh AM, Nemajerova A, Lazzara MJ, Altorki NK, Krainer A, Moll UM, Lowe SW, Cartegni L, Sordella R. Senturk S, et al. Among authors: sordella r. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):E3287-96. doi: 10.1073/pnas.1321640111. Epub 2014 Jul 29. Proc Natl Acad Sci U S A. 2014. PMID: 25074920 Free PMC article.

8

A rapid and scalable system for studying gene function in mice using conditional RNA interference.

Premsrirut PK, Dow LE, Kim SY, Camiolo M, Malone CD, Miething C, Scuoppo C, Zuber J, Dickins RA, Kogan SC, Shroyer KR, Sordella R, Hannon GJ, Lowe SW. Premsrirut PK, et al. Among authors: sordella r. Cell. 2011 Apr 1;145(1):145-58. doi: 10.1016/j.cell.2011.03.012. Cell. 2011. PMID: 21458673 Free PMC article.

9

DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma.

Xue W, Krasnitz A, Lucito R, Sordella R, Vanaelst L, Cordon-Cardo C, Singer S, Kuehnel F, Wigler M, Powers S, Zender L, Lowe SW. Xue W, et al. Among authors: sordella r. Genes Dev. 2008 Jun 1;22(11):1439-44. doi: 10.1101/gad.1672608. Genes Dev. 2008. PMID: 18519636 Free PMC article.

10

MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2.

Nowak DG, Cho H, Herzka T, Watrud K, DeMarco DV, Wang VM, Senturk S, Fellmann C, Ding D, Beinortas T, Kleinman D, Chen M, Sordella R, Wilkinson JE, Castillo-Martin M, Cordon-Cardo C, Robinson BD, Trotman LC. Nowak DG, et al. Among authors: sordella r. Cancer Discov. 2015 Jun;5(6):636-51. doi: 10.1158/2159-8290.CD-14-1113. Epub 2015 Mar 31. Cancer Discov. 2015. PMID: 25829425 Free PMC article.

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