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Influence of the N-terminus and the E2-loop onto the binding kinetics of the antagonist mepyramine and the partial agonist phenoprodifen to H(1)R.
Wittmann HJ, Seifert R, Strasser A. Wittmann HJ, et al. Among authors: strasser a. Biochem Pharmacol. 2011 Dec 15;82(12):1910-8. doi: 10.1016/j.bcp.2011.09.005. Epub 2011 Sep 16. Biochem Pharmacol. 2011. PMID: 21933664
Previous studies from our group revealed an influence of the exchange of N-terminus and E2-loop between hH(1)R and gpH(1)R onto affinity of phenoprodifen to H(1)R (Strasser A, Wittmann HJ, Seifert R, J Pharmacol Exp Ther 326:783-791, 2008). ...
Previous studies from our group revealed an influence of the exchange of N-terminus and E2-loop between hH(1)R and gpH(1)R onto affinity of …
hβ2R-Gαs complex: prediction versus crystal structure--how valuable are predictions based on molecular modeling studies?
Straßer A, Wittmann HJ. Straßer A, et al. J Mol Model. 2012 Jul;18(7):3439-44. doi: 10.1007/s00894-011-1305-z. Epub 2011 Dec 6. J Mol Model. 2012. PMID: 22143581
Utilizing a potential energy surface scan between hbeta(2)R and Galpha(s), a six-dimensional potential energy surface was obtained. Two significant minimum regions were located on this surface, and each was associated with a distinct hbeta(2)R-Galpha(s) compl …
Utilizing a potential energy surface scan between hbeta(2)R and Galpha(s), a six-dimensional potential energy surface was obta …
896 results