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Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.
Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I. Deuis JR, et al. Among authors: bosmans f. Sci Rep. 2017 Jan 20;7:40883. doi: 10.1038/srep40883. Sci Rep. 2017. PMID: 28106092 Free PMC article.
The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.
Wingerd JS, Mozar CA, Ussing CA, Murali SS, Chin YK, Cristofori-Armstrong B, Durek T, Gilchrist J, Vaughan CW, Bosmans F, Adams DJ, Lewis RJ, Alewood PF, Mobli M, Christie MJ, Rash LD. Wingerd JS, et al. Among authors: bosmans f. Sci Rep. 2017 Apr 20;7(1):974. doi: 10.1038/s41598-017-01129-0. Sci Rep. 2017. PMID: 28428547 Free PMC article.
Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.
Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I. Deuis JR, et al. Among authors: bosmans f. Sci Rep. 2017 May 26;7:46816. doi: 10.1038/srep46816. Sci Rep. 2017. PMID: 28548111 Free PMC article. No abstract available.
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain.
Osteen JD, Herzig V, Gilchrist J, Emrick JJ, Zhang C, Wang X, Castro J, Garcia-Caraballo S, Grundy L, Rychkov GY, Weyer AD, Dekan Z, Undheim EA, Alewood P, Stucky CL, Brierley SM, Basbaum AI, Bosmans F, King GF, Julius D. Osteen JD, et al. Among authors: bosmans f. Nature. 2016 Jun 23;534(7608):494-9. doi: 10.1038/nature17976. Epub 2016 Jun 6. Nature. 2016. PMID: 27281198 Free PMC article.
Spider peptide toxins as leads for drug development.
Escoubas P, Bosmans F. Escoubas P, et al. Among authors: bosmans f. Expert Opin Drug Discov. 2007 Jun;2(6):823-35. doi: 10.1517/17460441.2.6.823. Expert Opin Drug Discov. 2007. PMID: 23489000
85 results