Hayes MA - Search Results

1

The self-sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5-hydroxylation of diclofenac.

Klenk JM, Nebel BA, Porter JL, Kulig JK, Hussain SA, Richter SM, Tavanti M, Turner NJ, Hayes MA, Hauer B, Flitsch SL. Klenk JM, et al. Among authors: hayes ma. Biotechnol J. 2017 Mar;12(3). doi: 10.1002/biot.201600520. Epub 2017 Feb 8. Biotechnol J. 2017. PMID: 28098428

2

A P450 fusion library of heme domains from Rhodococcus jostii RHA1 and its evaluation for the biotransformation of drug molecules.

Kulig JK, Spandolf C, Hyde R, Ruzzini AC, Eltis LD, Grönberg G, Hayes MA, Grogan G. Kulig JK, et al. Among authors: hayes ma. Bioorg Med Chem. 2015 Sep 1;23(17):5603-9. doi: 10.1016/j.bmc.2015.07.025. Epub 2015 Jul 21. Bioorg Med Chem. 2015. PMID: 26234905

3

P450_BM3 fused to phosphite dehydrogenase allows phosphite-driven selective oxidations.

Beyer N, Kulig JK, Bartsch A, Hayes MA, Janssen DB, Fraaije MW. Beyer N, et al. Among authors: hayes ma. Appl Microbiol Biotechnol. 2017 Mar;101(6):2319-2331. doi: 10.1007/s00253-016-7993-7. Epub 2016 Nov 29. Appl Microbiol Biotechnol. 2017. PMID: 27900443 Free PMC article.

4

Exploring PTDH-P450BM3 Variants for the Synthesis of Drug Metabolites.

Beyer N, Kulig JK, Fraaije MW, Hayes MA, Janssen DB. Beyer N, et al. Among authors: hayes ma. Chembiochem. 2018 Feb 16;19(4):326-337. doi: 10.1002/cbic.201700470. Epub 2018 Jan 17. Chembiochem. 2018. PMID: 29181885

5

Enzymatic Late-Stage Modifications: Better Late Than Never.

Romero E, Jones BS, Hogg BN, Rué Casamajo A, Hayes MA, Flitsch SL, Turner NJ, Schnepel C. Romero E, et al. Among authors: hayes ma. Angew Chem Int Ed Engl. 2021 Jul 26;60(31):16824-16855. doi: 10.1002/anie.202014931. Epub 2021 Mar 8. Angew Chem Int Ed Engl. 2021. PMID: 33453143 Free PMC article. Review.

6

Biocatalysis in Drug Design: Engineered Reductive Aminases (RedAms) Are Used to Access Chiral Building Blocks with Multiple Stereocenters.

Casamajo AR, Yu Y, Schnepel C, Morrill C, Barker R, Levy CW, Finnigan J, Spelling V, Westerlund K, Petchey M, Sheppard RJ, Lewis RJ, Falcioni F, Hayes MA, Turner NJ. Casamajo AR, et al. Among authors: hayes ma. J Am Chem Soc. 2023 Oct 11;145(40):22041-22046. doi: 10.1021/jacs.3c07010. Epub 2023 Oct 2. J Am Chem Soc. 2023. PMID: 37782882 Free PMC article.

7

Enzymkatalysierte späte Modifizierungen: Besser spät als nie.

Romero E, Jones BS, Hogg BN, Rué Casamajo A, Hayes MA, Flitsch SL, Turner NJ, Schnepel C. Romero E, et al. Among authors: hayes ma. Angew Chem Weinheim Bergstr Ger. 2021 Jul 26;133(31):16962-16993. doi: 10.1002/ange.202014931. Epub 2021 Mar 8. Angew Chem Weinheim Bergstr Ger. 2021. PMID: 38505660 Free PMC article. Review.

8

Discovery of a Novel Microsomal Epoxide Hydrolase-Catalyzed Hydration of a Spiro Oxetane.

Li XQ, Hayes MA, Grönberg G, Berggren K, Castagnoli N Jr, Weidolf L. Li XQ, et al. Among authors: hayes ma. Drug Metab Dispos. 2016 Aug;44(8):1341-8. doi: 10.1124/dmd.116.071142. Epub 2016 Jun 2. Drug Metab Dispos. 2016. PMID: 27256986

9

CYP3A Specifically Catalyzes 1β-Hydroxylation of Deoxycholic Acid: Characterization and Enzymatic Synthesis of a Potential Novel Urinary Biomarker for CYP3A Activity.

Hayes MA, Li XQ, Grönberg G, Diczfalusy U, Andersson TB. Hayes MA, et al. Drug Metab Dispos. 2016 Sep;44(9):1480-9. doi: 10.1124/dmd.116.070805. Epub 2016 Jul 11. Drug Metab Dispos. 2016. PMID: 27402728

10

Oxetane Substrates of Human Microsomal Epoxide Hydrolase.

Toselli F, Fredenwall M, Svensson P, Li XQ, Johansson A, Weidolf L, Hayes MA. Toselli F, et al. Among authors: hayes ma. Drug Metab Dispos. 2017 Aug;45(8):966-973. doi: 10.1124/dmd.117.076489. Epub 2017 Jun 9. Drug Metab Dispos. 2017. PMID: 28600384

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