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ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile.
Yamamoto R, Okada Y, Hirose J, Koshika T, Kawato Y, Maeda M, Saito R, Hattori K, Harada H, Nagasaka Y, Morokata T. Yamamoto R, et al. Among authors: hirose j. PLoS One. 2014 Oct 27;9(10):e110819. doi: 10.1371/journal.pone.0110819. eCollection 2014. PLoS One. 2014. PMID: 25347187 Free PMC article.
Replacement of mycophenolate mofetil with a JAK inhibitor, AS2553627, in combination with low-dose tacrolimus, for renal allograft rejection in non-human primates.
Nakamura K, Oshima S, Maeda M, Morio H, Fukahori H, Nakanishi T, Tsujimoto S, Hirose J, Noto T, Hamakawa N, Inami M, Morokata T. Nakamura K, et al. Among authors: hirose j. Int Immunopharmacol. 2018 Nov;64:201-207. doi: 10.1016/j.intimp.2018.08.029. Epub 2018 Sep 7. Int Immunopharmacol. 2018. PMID: 30195818
ASP1126, a Novel Sphingosine-1-Phosphate-Selective Agonist With a Favorable Safety Profile, Prolongs Allograft Survival in Rats and Nonhuman Primates in Combination With Tacrolimus With a Broad Safety Margin for Bradycardia.
Okimoto A, Yamamoto R, Hirose J, Shimatani K, Koshika T, Maeda M, Hattori K, Morokata T. Okimoto A, et al. Among authors: hirose j. Transplant Proc. 2019 Jul-Aug;51(6):2081-2098. doi: 10.1016/j.transproceed.2019.05.012. Transplant Proc. 2019. PMID: 31399186
A sphingosine-1-phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigration.
Yamamoto R, Aoki T, Koseki H, Fukuda M, Hirose J, Tsuji K, Takizawa K, Nakamura S, Miyata H, Hamakawa N, Kasuya H, Nozaki K, Hirayama Y, Aramori I, Narumiya S. Yamamoto R, et al. Among authors: hirose j. Br J Pharmacol. 2017 Jul;174(13):2085-2101. doi: 10.1111/bph.13820. Epub 2017 May 27. Br J Pharmacol. 2017. PMID: 28409823 Free PMC article.
306 results