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Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.
J Med Chem. 2017 Feb 9;60(3):913-927. doi: 10.1021/acs.jmedchem.6b00871. Epub 2017 Jan 19.
J Med Chem. 2017.
PMID: 28072531
Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: in vitro profiling and in vivo evaluation.
Semple G, Tran TA, Kramer B, Hsu D, Han S, Choi J, Vallar P, Casper MD, Zou N, Hauser EK, Thomsen W, Whelan K, Sengupta D, Morgan M, Sekiguchi Y, Kanuma K, Chaki S, Grottick AJ.
Semple G, et al. Among authors: vallar p.
Bioorg Med Chem Lett. 2009 Nov 1;19(21):6166-71. doi: 10.1016/j.bmcl.2009.09.003. Epub 2009 Sep 6.
Bioorg Med Chem Lett. 2009.
PMID: 19773162
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Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat.
Tran TA, Shin YJ, Kramer B, Choi J, Zou N, Vallar P, Martens P, Boatman PD, Adams JW, Ramirez J, Shi Y, Morgan M, Unett DJ, Chang S, Shu HH, Tung SF, Semple G.
Tran TA, et al. Among authors: vallar p.
Bioorg Med Chem Lett. 2015 Mar 1;25(5):1030-5. doi: 10.1016/j.bmcl.2015.01.024. Epub 2015 Jan 22.
Bioorg Med Chem Lett. 2015.
PMID: 25666818
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Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic.
Krishnan R, Tulinsky A, Vlasuk GP, Pearson D, Vallar P, Bergum P, Brunck TK, Ripka WC.
Krishnan R, et al. Among authors: vallar p.
Protein Sci. 1996 Mar;5(3):422-33. doi: 10.1002/pro.5560050303.
Protein Sci. 1996.
PMID: 8868478
Free PMC article.
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