Yarwood SJ - Search Results

1

The cyclic AMP phosphodiesterase 4D5 (PDE4D5)/receptor for activated C-kinase 1 (RACK1) signalling complex as a sensor of the extracellular nano-environment.

Yarwood SJ, Parnell E, Bird RJ. Yarwood SJ, et al. Cell Signal. 2017 Jul;35:282-289. doi: 10.1016/j.cellsig.2017.01.013. Epub 2017 Jan 6. Cell Signal. 2017. PMID: 28069443 Review.

2

In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targeting.

Beard MB, Huston E, Campbell L, Gall I, McPhee I, Yarwood S, Scotland G, Houslay MD. Beard MB, et al. Cell Signal. 2002 May;14(5):453-65. doi: 10.1016/s0898-6568(01)00264-9. Cell Signal. 2002. PMID: 11882390

3

Activation of protein kinase Calpha by EPAC1 is required for the ERK- and CCAAT/enhancer-binding protein beta-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells.

Borland G, Bird RJ, Palmer TM, Yarwood SJ. Borland G, et al. Among authors: yarwood sj. J Biol Chem. 2009 Jun 26;284(26):17391-403. doi: 10.1074/jbc.M109.015370. Epub 2009 May 7. J Biol Chem. 2009. PMID: 19423709 Free PMC article.

4

Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic AMP via Epac1-dependent induction of suppressor of cytokine signalling-3.

Woolson HD, Thomson VS, Rutherford C, Yarwood SJ, Palmer TM. Woolson HD, et al. Among authors: yarwood sj. Cell Signal. 2009 Nov;21(11):1706-15. doi: 10.1016/j.cellsig.2009.07.009. Epub 2009 Jul 24. Cell Signal. 2009. PMID: 19632320

5

Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C.

Bird RJ, Baillie GS, Yarwood SJ. Bird RJ, et al. Among authors: yarwood sj. Biochem J. 2010 Nov 15;432(1):207-16. doi: 10.1042/BJ20101010. Biochem J. 2010. PMID: 20819076 Free PMC article.

6

Regulation of the inflammatory response of vascular endothelial cells by EPAC1.

Parnell E, Smith BO, Palmer TM, Terrin A, Zaccolo M, Yarwood SJ. Parnell E, et al. Among authors: yarwood sj. Br J Pharmacol. 2012 May;166(2):434-46. doi: 10.1111/j.1476-5381.2011.01808.x. Br J Pharmacol. 2012. PMID: 22145651 Free PMC article. Review.

7

The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun.

Wiejak J, Dunlop J, Stoyle C, Lappin G, McIlroy A, Pediani JD, Gao S, Yarwood SJ. Wiejak J, et al. Among authors: yarwood sj. Cell Signal. 2012 Aug;24(8):1690-9. doi: 10.1016/j.cellsig.2012.04.016. Epub 2012 Apr 25. Cell Signal. 2012. PMID: 22561846 Free PMC article.

8

Interactions between Epac1 and ezrin in the control of endothelial barrier function.

Parnell E, Yarwood SJ. Parnell E, et al. Among authors: yarwood sj. Biochem Soc Trans. 2014 Apr;42(2):274-8. doi: 10.1042/BST20130271. Biochem Soc Trans. 2014. PMID: 24646230 Review.

9

The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal.

Parnell E, Smith BO, Yarwood SJ. Parnell E, et al. Among authors: yarwood sj. Cell Signal. 2015 May;27(5):989-96. doi: 10.1016/j.cellsig.2015.02.009. Epub 2015 Feb 12. Cell Signal. 2015. PMID: 25683912 Free PMC article.

10

The future of EPAC-targeted therapies: agonism versus antagonism.

Parnell E, Palmer TM, Yarwood SJ. Parnell E, et al. Among authors: yarwood sj. Trends Pharmacol Sci. 2015 Apr;36(4):203-14. doi: 10.1016/j.tips.2015.02.003. Epub 2015 Mar 3. Trends Pharmacol Sci. 2015. PMID: 25744542 Free PMC article. Review.

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