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Intratumoral hu14.18-IL-2 (IC) induces local and systemic antitumor effects that involve both activated T and NK cells as well as enhanced IC retention.
Yang RK, Kalogriopoulos NA, Rakhmilevich AL, Ranheim EA, Seo S, Kim K, Alderson KL, Gan J, Reisfeld RA, Gillies SD, Hank JA, Sondel PM. Yang RK, et al. Among authors: gillies sd. J Immunol. 2012 Sep 1;189(5):2656-64. doi: 10.4049/jimmunol.1200934. Epub 2012 Jul 27. J Immunol. 2012. PMID: 22844125 Free PMC article.
Enhancement of the anti-melanoma response of Hu14.18K322A by αCD40 + CpG.
Alderson KL, Luangrath M, Elsenheimer MM, Gillies SD, Navid F, Rakhmilevich AL, Sondel PM. Alderson KL, et al. Among authors: gillies sd. Cancer Immunol Immunother. 2013 Apr;62(4):665-75. doi: 10.1007/s00262-012-1372-8. Epub 2012 Nov 15. Cancer Immunol Immunother. 2013. PMID: 23151945 Free PMC article.
Tumor-Specific Inhibition of In Situ Vaccination by Distant Untreated Tumor Sites.
Morris ZS, Guy EI, Werner LR, Carlson PM, Heinze CM, Kler JS, Busche SM, Jaquish AA, Sriramaneni RN, Carmichael LL, Loibner H, Gillies SD, Korman AJ, Erbe AK, Hank JA, Rakhmilevich AL, Harari PM, Sondel PM. Morris ZS, et al. Among authors: gillies sd. Cancer Immunol Res. 2018 Jul;6(7):825-834. doi: 10.1158/2326-6066.CIR-17-0353. Epub 2018 May 10. Cancer Immunol Res. 2018. PMID: 29748391 Free PMC article.
MUC16 suppresses human and murine innate immune responses.
Felder M, Kapur A, Rakhmilevich AL, Qu X, Sondel PM, Gillies SD, Connor J, Patankar MS. Felder M, et al. Among authors: gillies sd. Gynecol Oncol. 2019 Mar;152(3):618-628. doi: 10.1016/j.ygyno.2018.12.023. Epub 2019 Jan 6. Gynecol Oncol. 2019. PMID: 30626487 Free PMC article.
Combined innate and adaptive immunotherapy overcomes resistance of immunologically cold syngeneic murine neuroblastoma to checkpoint inhibition.
Voeller J, Erbe AK, Slowinski J, Rasmussen K, Carlson PM, Hoefges A, VandenHeuvel S, Stuckwisch A, Wang X, Gillies SD, Patel RB, Farrel A, Rokita JL, Maris J, Hank JA, Morris ZS, Rakhmilevich AL, Sondel PM. Voeller J, et al. Among authors: gillies sd. J Immunother Cancer. 2019 Dec 6;7(1):344. doi: 10.1186/s40425-019-0823-6. J Immunother Cancer. 2019. PMID: 31810498 Free PMC article.
In situ Vaccine Plus Checkpoint Blockade Induces Memory Humoral Response.
Baniel CC, Heinze CM, Hoefges A, Sumiec EG, Hank JA, Carlson PM, Jin WJ, Patel RB, Sriramaneni RN, Gillies SD, Erbe AK, Schwarz CN, Pieper AA, Rakhmilevich AL, Sondel PM, Morris ZS. Baniel CC, et al. Among authors: gillies sd. Front Immunol. 2020 Jul 24;11:1610. doi: 10.3389/fimmu.2020.01610. eCollection 2020. Front Immunol. 2020. PMID: 32849544 Free PMC article.
Intratumoral immunocytokine treatment results in enhanced antitumor effects.
Johnson EE, Lum HD, Rakhmilevich AL, Schmidt BE, Furlong M, Buhtoiarov IN, Hank JA, Raubitschek A, Colcher D, Reisfeld RA, Gillies SD, Sondel PM. Johnson EE, et al. Among authors: gillies sd. Cancer Immunol Immunother. 2008 Dec;57(12):1891-902. doi: 10.1007/s00262-008-0519-0. Epub 2008 Apr 26. Cancer Immunol Immunother. 2008. PMID: 18438664 Free PMC article.
Differential internalization of hu14.18-IL2 immunocytokine by NK and tumor cell: impact on conjugation, cytotoxicity, and targeting.
Buhtoiarov IN, Neal ZC, Gan J, Buhtoiarova TN, Patankar MS, Gubbels JA, Hank JA, Yamane B, Rakhmilevich AL, Reisfeld RA, Gillies SD, Sondel PM. Buhtoiarov IN, et al. Among authors: gillies sd. J Leukoc Biol. 2011 Apr;89(4):625-38. doi: 10.1189/jlb.0710422. Epub 2011 Jan 19. J Leukoc Biol. 2011. PMID: 21248148 Free PMC article.
157 results