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Bicyclic enol cyclocarbamates inhibit penicillin-binding proteins.
Dockerty P, Edens JG, Tol MB, Morales Angeles D, Domenech A, Liu Y, Hirsch AK, Veening JW, Scheffers DJ, Witte MD. Dockerty P, et al. Among authors: hirsch ak. Org Biomol Chem. 2017 Jan 25;15(4):894-910. doi: 10.1039/c6ob01664b. Org Biomol Chem. 2017. PMID: 28045164
Validation of a homology model of Mycobacterium tuberculosis DXS: rationalization of observed activities of thiamine derivatives as potent inhibitors of two orthologues of DXS.
Masini T, Lacy B, Monjas L, Hawksley D, de Voogd AR, Illarionov B, Iqbal A, Leeper FJ, Fischer M, Kontoyianni M, Hirsch AK. Masini T, et al. Among authors: hirsch ak. Org Biomol Chem. 2015 Dec 14;13(46):11263-77. doi: 10.1039/c5ob01666e. Epub 2015 Sep 28. Org Biomol Chem. 2015. PMID: 26411373
Pentapeptide-rich peptidoglycan at the Bacillus subtilis cell-division site.
Morales Angeles D, Liu Y, Hartman AM, Borisova M, de Sousa Borges A, de Kok N, Beilharz K, Veening JW, Mayer C, Hirsch AK, Scheffers DJ. Morales Angeles D, et al. Among authors: hirsch ak. Mol Microbiol. 2017 Apr;104(2):319-333. doi: 10.1111/mmi.13629. Epub 2017 Feb 6. Mol Microbiol. 2017. PMID: 28118510 Free article.
Saccharide-Containing Dynamic Proteoids.
Liu Y, Stuart MCA, Witte MD, Buhler E, Hirsch AKH. Liu Y, et al. Chemistry. 2017 Nov 16;23(64):16162-16166. doi: 10.1002/chem.201703584. Epub 2017 Oct 25. Chemistry. 2017. PMID: 28981987 Free PMC article.
Dynamic Proteoids Generated From Dipeptide-Based Monomers.
Liu Y, Stuart MCA, Buhler E, Hirsch AKH. Liu Y, et al. Macromol Rapid Commun. 2018 Jul;39(13):e1800099. doi: 10.1002/marc.201800099. Epub 2018 May 28. Macromol Rapid Commun. 2018. PMID: 29806088 Free article.
Delivery system for budesonide based on lipid-DNA.
Liu Y, Bos IST, Oenema TA, Meurs H, Maarsingh H, Hirsch AKH. Liu Y, et al. Eur J Pharm Biopharm. 2018 Sep;130:123-127. doi: 10.1016/j.ejpb.2018.06.012. Epub 2018 Jun 14. Eur J Pharm Biopharm. 2018. PMID: 29908939
Protein-Templated Hit Identification through an Ugi Four-Component Reaction*.
Mancini F, Unver MY, Elgaher WAM, Jumde VR, Alhayek A, Lukat P, Herrmann J, Witte MD, Köck M, Blankenfeldt W, Müller R, Hirsch AKH. Mancini F, et al. Chemistry. 2020 Nov 17;26(64):14585-14593. doi: 10.1002/chem.202002250. Epub 2020 Sep 30. Chemistry. 2020. PMID: 32428268 Free PMC article.
Flotillin-mediated membrane fluidity controls peptidoglycan synthesis and MreB movement.
Zielińska A, Savietto A, de Sousa Borges A, Martinez D, Berbon M, Roelofsen JR, Hartman AM, de Boer R, Van der Klei IJ, Hirsch AK, Habenstein B, Bramkamp M, Scheffers DJ. Zielińska A, et al. Among authors: hirsch ak. Elife. 2020 Jul 14;9:e57179. doi: 10.7554/eLife.57179. Elife. 2020. PMID: 32662773 Free PMC article.
150 results