de Vries H - Search Results

1

Cannabinoid CB₂ receptor ligand profiling reveals biased signalling and off-target activity.

Soethoudt M, Grether U, Fingerle J, Grim TW, Fezza F, de Petrocellis L, Ullmer C, Rothenhäusler B, Perret C, van Gils N, Finlay D, MacDonald C, Chicca A, Gens MD, Stuart J, de Vries H, Mastrangelo N, Xia L, Alachouzos G, Baggelaar MP, Martella A, Mock ED, Deng H, Heitman LH, Connor M, Di Marzo V, Gertsch J, Lichtman AH, Maccarrone M, Pacher P, Glass M, van der Stelt M. Soethoudt M, et al. Among authors: de vries h, de petrocellis l. Nat Commun. 2017 Jan 3;8:13958. doi: 10.1038/ncomms13958. Nat Commun. 2017. PMID: 28045021 Free PMC article.

2

Scintillation proximity assay (SPA) as a new approach to determine a ligand's kinetic profile. A case in point for the adenosine A1 receptor.

Xia L, de Vries H, IJzerman AP, Heitman LH. Xia L, et al. Among authors: de vries h. Purinergic Signal. 2016 Mar;12(1):115-26. doi: 10.1007/s11302-015-9485-0. Epub 2015 Dec 9. Purinergic Signal. 2016. PMID: 26647040 Free PMC article.

3

Agonists for the adenosine A1 receptor with tunable residence time. A Case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines.

Louvel J, Guo D, Agliardi M, Mocking TA, Kars R, Pham TP, Xia L, de Vries H, Brussee J, Heitman LH, Ijzerman AP. Louvel J, et al. Among authors: de vries h. J Med Chem. 2014 Apr 24;57(8):3213-22. doi: 10.1021/jm401643m. Epub 2014 Apr 3. J Med Chem. 2014. PMID: 24669958

4

Kinetics of human cannabinoid 1 (CB1) receptor antagonists: Structure-kinetics relationships (SKR) and implications for insurmountable antagonism.

Xia L, de Vries H, Yang X, Lenselink EB, Kyrizaki A, Barth F, Louvel J, Dreyer MK, van der Es D, IJzerman AP, Heitman LH. Xia L, et al. Among authors: de vries h. Biochem Pharmacol. 2018 May;151:166-179. doi: 10.1016/j.bcp.2017.10.014. Epub 2017 Nov 2. Biochem Pharmacol. 2018. PMID: 29102677 Free article.

5

Structure-Affinity Relationships and Structure-Kinetic Relationships of 1,2-Diarylimidazol-4-carboxamide Derivatives as Human Cannabinoid 1 Receptor Antagonists.

Xia L, de Vries H, Lenselink EB, Louvel J, Waring MJ, Cheng L, Pahlén S, Petersson MJ, Schell P, Olsson RI, Heitman LH, Sheppard RJ, IJzerman AP. Xia L, et al. Among authors: de vries h. J Med Chem. 2017 Dec 14;60(23):9545-9564. doi: 10.1021/acs.jmedchem.7b00861. Epub 2017 Nov 21. J Med Chem. 2017. PMID: 29111736 Free PMC article.

6

Optimization of the metabolic stability of a fluorinated cannabinoid receptor subtype 2 (CB₂) ligand designed for PET studies.

Heimann D, Börgel F, de Vries H, Patberg M, Jan-Smith E, Frehland B, Schepmann D, Heitman LH, Wünsch B. Heimann D, et al. Among authors: de vries h. Eur J Med Chem. 2018 Feb 25;146:409-422. doi: 10.1016/j.ejmech.2018.01.048. Epub 2018 Jan 31. Eur J Med Chem. 2018. PMID: 29407967

7

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.

Zheng Y, Qin L, Zacarías NV, de Vries H, Han GW, Gustavsson M, Dabros M, Zhao C, Cherney RJ, Carter P, Stamos D, Abagyan R, Cherezov V, Stevens RC, IJzerman AP, Heitman LH, Tebben A, Kufareva I, Handel TM. Zheng Y, et al. Among authors: de vries h. Nature. 2016 Dec 15;540(7633):458-461. doi: 10.1038/nature20605. Epub 2016 Dec 7. Nature. 2016. PMID: 27926736 Free PMC article.

8

Optimization of pharmacokinetic properties by modification of a carbazole-based cannabinoid receptor subtype 2 (CB₂) ligand.

Heimann D, Börgel F, de Vries H, Bachmann K, Rose VE, Frehland B, Schepmann D, Heitman LH, Wünsch B. Heimann D, et al. Among authors: de vries h. Eur J Med Chem. 2018 Jan 1;143:1436-1447. doi: 10.1016/j.ejmech.2017.10.049. Epub 2017 Oct 16. Eur J Med Chem. 2018. PMID: 29126730

9

Substituted terphenyl compounds as the first class of low molecular weight allosteric inhibitors of the luteinizing hormone receptor.

Heitman LH, Narlawar R, de Vries H, Willemsen MN, Wolfram D, Brussee J, Ijzerman AP. Heitman LH, et al. Among authors: de vries h. J Med Chem. 2009 Apr 9;52(7):2036-42. doi: 10.1021/jm801561h. J Med Chem. 2009. PMID: 19296599

10

A two-state model for the kinetics of competitive radioligand binding.

Guo D, Peletier LA, Bridge L, Keur W, de Vries H, Zweemer A, Heitman LH, IJzerman AP. Guo D, et al. Among authors: de vries h. Br J Pharmacol. 2018 May;175(10):1719-1730. doi: 10.1111/bph.14184. Epub 2018 Apr 17. Br J Pharmacol. 2018. PMID: 29486053 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

1,818 results

Search Page