Xia L - Search Results

1

Cannabinoid CB₂ receptor ligand profiling reveals biased signalling and off-target activity.

Soethoudt M, Grether U, Fingerle J, Grim TW, Fezza F, de Petrocellis L, Ullmer C, Rothenhäusler B, Perret C, van Gils N, Finlay D, MacDonald C, Chicca A, Gens MD, Stuart J, de Vries H, Mastrangelo N, Xia L, Alachouzos G, Baggelaar MP, Martella A, Mock ED, Deng H, Heitman LH, Connor M, Di Marzo V, Gertsch J, Lichtman AH, Maccarrone M, Pacher P, Glass M, van der Stelt M. Soethoudt M, et al. Among authors: xia l. Nat Commun. 2017 Jan 3;8:13958. doi: 10.1038/ncomms13958. Nat Commun. 2017. PMID: 28045021 Free PMC article.

2

Scintillation proximity assay (SPA) as a new approach to determine a ligand's kinetic profile. A case in point for the adenosine A1 receptor.

Xia L, de Vries H, IJzerman AP, Heitman LH. Xia L, et al. Purinergic Signal. 2016 Mar;12(1):115-26. doi: 10.1007/s11302-015-9485-0. Epub 2015 Dec 9. Purinergic Signal. 2016. PMID: 26647040 Free PMC article.

3

Cellular Assay to Study β-Arrestin Recruitment by the Cannabinoid Receptors 1 and 2.

Bouma J, Soethoudt M, van Gils N, Xia L, van der Stelt M, Heitman LH. Bouma J, et al. Among authors: xia l. Methods Mol Biol. 2023;2576:189-199. doi: 10.1007/978-1-0716-2728-0_15. Methods Mol Biol. 2023. PMID: 36152187

4

Agonists for the adenosine A1 receptor with tunable residence time. A Case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines.

Louvel J, Guo D, Agliardi M, Mocking TA, Kars R, Pham TP, Xia L, de Vries H, Brussee J, Heitman LH, Ijzerman AP. Louvel J, et al. Among authors: xia l. J Med Chem. 2014 Apr 24;57(8):3213-22. doi: 10.1021/jm401643m. Epub 2014 Apr 3. J Med Chem. 2014. PMID: 24669958

5

Kinetics of human cannabinoid 1 (CB1) receptor antagonists: Structure-kinetics relationships (SKR) and implications for insurmountable antagonism.

Xia L, de Vries H, Yang X, Lenselink EB, Kyrizaki A, Barth F, Louvel J, Dreyer MK, van der Es D, IJzerman AP, Heitman LH. Xia L, et al. Biochem Pharmacol. 2018 May;151:166-179. doi: 10.1016/j.bcp.2017.10.014. Epub 2017 Nov 2. Biochem Pharmacol. 2018. PMID: 29102677 Free article.

6

Structure-Affinity Relationships and Structure-Kinetic Relationships of 1,2-Diarylimidazol-4-carboxamide Derivatives as Human Cannabinoid 1 Receptor Antagonists.

Xia L, de Vries H, Lenselink EB, Louvel J, Waring MJ, Cheng L, Pahlén S, Petersson MJ, Schell P, Olsson RI, Heitman LH, Sheppard RJ, IJzerman AP. Xia L, et al. J Med Chem. 2017 Dec 14;60(23):9545-9564. doi: 10.1021/acs.jmedchem.7b00861. Epub 2017 Nov 21. J Med Chem. 2017. PMID: 29111736 Free PMC article.

7

Structure-Affinity Relationships and Structure-Kinetics Relationships of Pyrido[2,1-f]purine-2,4-dione Derivatives as Human Adenosine A₃ Receptor Antagonists.

Xia L, Burger WAC, van Veldhoven JPD, Kuiper BJ, van Duijl TT, Lenselink EB, Paasman E, Heitman LH, IJzerman AP. Xia L, et al. J Med Chem. 2017 Sep 14;60(17):7555-7568. doi: 10.1021/acs.jmedchem.7b00950. Epub 2017 Aug 30. J Med Chem. 2017. PMID: 28806076 Free PMC article.

8

A binding kinetics study of human adenosine A₃ receptor agonists.

Xia L, Kyrizaki A, Tosh DK, van Duijl TT, Roorda JC, Jacobson KA, IJzerman AP, Heitman LH. Xia L, et al. Biochem Pharmacol. 2018 Jul;153:248-259. doi: 10.1016/j.bcp.2017.12.026. Epub 2018 Jan 3. Biochem Pharmacol. 2018. PMID: 29305857 Free PMC article.

9

Binding kinetics of ZM241385 derivatives at the human adenosine A2A receptor.

Guo D, Xia L, van Veldhoven JP, Hazeu M, Mocking T, Brussee J, Ijzerman AP, Heitman LH. Guo D, et al. Among authors: xia l. ChemMedChem. 2014 Apr;9(4):752-61. doi: 10.1002/cmdc.201300474. Epub 2014 Mar 3. ChemMedChem. 2014. PMID: 24591302

10

A live cell NanoBRET binding assay allows the study of ligand-binding kinetics to the adenosine A₃ receptor.

Bouzo-Lorenzo M, Stoddart LA, Xia L, IJzerman AP, Heitman LH, Briddon SJ, Hill SJ. Bouzo-Lorenzo M, et al. Among authors: xia l. Purinergic Signal. 2019 Jun;15(2):139-153. doi: 10.1007/s11302-019-09650-9. Epub 2019 Mar 27. Purinergic Signal. 2019. PMID: 30919204 Free PMC article.

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