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Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity.
Soethoudt M, Grether U, Fingerle J, Grim TW, Fezza F, de Petrocellis L, Ullmer C, Rothenhäusler B, Perret C, van Gils N, Finlay D, MacDonald C, Chicca A, Gens MD, Stuart J, de Vries H, Mastrangelo N, Xia L, Alachouzos G, Baggelaar MP, Martella A, Mock ED, Deng H, Heitman LH, Connor M, Di Marzo V, Gertsch J, Lichtman AH, Maccarrone M, Pacher P, Glass M, van der Stelt M. Soethoudt M, et al. Among authors: baggelaar mp. Nat Commun. 2017 Jan 3;8:13958. doi: 10.1038/ncomms13958. Nat Commun. 2017. PMID: 28045021 Free PMC article.
Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-α in brain.
Baggelaar MP, Janssen FJ, van Esbroeck AC, den Dulk H, Allarà M, Hoogendoorn S, McGuire R, Florea BI, Meeuwenoord N, van den Elst H, van der Marel GA, Brouwer J, Di Marzo V, Overkleeft HS, van der Stelt M. Baggelaar MP, et al. Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12081-5. doi: 10.1002/anie.201306295. Epub 2013 Oct 31. Angew Chem Int Ed Engl. 2013. PMID: 24173880 No abstract available.
Development of an acid ceramidase activity-based probe.
Ouairy CM, Ferraz MJ, Boot RG, Baggelaar MP, van der Stelt M, Appelman M, van der Marel GA, Florea BI, Aerts JM, Overkleeft HS. Ouairy CM, et al. Among authors: baggelaar mp. Chem Commun (Camb). 2015 Apr 11;51(28):6161-3. doi: 10.1039/c5cc00356c. Chem Commun (Camb). 2015. PMID: 25748248
Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons.
Baggelaar MP, Chameau PJ, Kantae V, Hummel J, Hsu KL, Janssen F, van der Wel T, Soethoudt M, Deng H, den Dulk H, Allarà M, Florea BI, Di Marzo V, Wadman WJ, Kruse CG, Overkleeft HS, Hankemeier T, Werkman TR, Cravatt BF, van der Stelt M. Baggelaar MP, et al. J Am Chem Soc. 2015 Jul 15;137(27):8851-7. doi: 10.1021/jacs.5b04883. Epub 2015 Jul 1. J Am Chem Soc. 2015. PMID: 26083464 Free PMC article.
The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity.
Mukhopadhyay P, Baggelaar M, Erdelyi K, Cao Z, Cinar R, Fezza F, Ignatowska-Janlowska B, Wilkerson J, van Gils N, Hansen T, Ruben M, Soethoudt M, Heitman L, Kunos G, Maccarrone M, Lichtman A, Pacher P, Van der Stelt M. Mukhopadhyay P, et al. Br J Pharmacol. 2016 Feb;173(3):446-58. doi: 10.1111/bph.13338. Epub 2016 Jan 15. Br J Pharmacol. 2016. PMID: 26398481 Free PMC article.
Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition.
Ogasawara D, Deng H, Viader A, Baggelaar MP, Breman A, den Dulk H, van den Nieuwendijk AM, Soethoudt M, van der Wel T, Zhou J, Overkleeft HS, Sanchez-Alavez M, Mori S, Nguyen W, Conti B, Liu X, Chen Y, Liu QS, Cravatt BF, van der Stelt M. Ogasawara D, et al. Among authors: baggelaar mp. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):26-33. doi: 10.1073/pnas.1522364112. Epub 2015 Dec 14. Proc Natl Acad Sci U S A. 2016. PMID: 26668358 Free PMC article.
29 results