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A non-BRICHOS SFTPC mutant (SP-CI73T) linked to interstitial lung disease promotes a late block in macroautophagy disrupting cellular proteostasis and mitophagy.
Hawkins A, Guttentag SH, Deterding R, Funkhouser WK, Goralski JL, Chatterjee S, Mulugeta S, Beers MF. Hawkins A, et al. Among authors: mulugeta s. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 1;308(1):L33-47. doi: 10.1152/ajplung.00217.2014. Epub 2014 Oct 24. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 25344067 Free PMC article.
The common ABCA3E292V variant disrupts AT2 cell quality control and increases susceptibility to lung injury and aberrant remodeling.
Tomer Y, Wambach J, Knudsen L, Zhao M, Rodriguez LR, Murthy A, White FV, Venosa A, Katzen J, Ochs M, Hamvas A, Beers MF, Mulugeta S. Tomer Y, et al. Among authors: mulugeta s. Am J Physiol Lung Cell Mol Physiol. 2021 Aug 1;321(2):L291-L307. doi: 10.1152/ajplung.00400.2020. Epub 2021 Jun 16. Am J Physiol Lung Cell Mol Physiol. 2021. PMID: 34132118 Free PMC article.
67 results