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Metabolic studies using recombinant escherichia coli cells producing rat mitochondrial CYP24 CYP24 can convert 1alpha,25-dihydroxyvitamin D3 to calcitroic acid.
Sakaki T, Sawada N, Nonaka Y, Ohyama Y, Inouye K. Sakaki T, et al. Eur J Biochem. 1999 May;262(1):43-8. doi: 10.1046/j.1432-1327.1999.00375.x. Eur J Biochem. 1999. PMID: 10231362 Free article.
Previously we expressed rat 25-hydroxyvitamin D3 24-hydroxylase (CYP24) cDNA in Escherichia coli JM109 and showed that CYP24 catalyses three-step monooxygenation towards 25-hydroxyvitamin D3 and 1alpha,25-dihydroxyvitamin D3 [Akiyoshi-Shibata, M., Sakaki, T., Ohyama …
Previously we expressed rat 25-hydroxyvitamin D3 24-hydroxylase (CYP24) cDNA in Escherichia coli JM109 and showed that CYP24 catalyses three …
Metabolism of vitamin D(3) by human CYP27A1.
Sawada N, Sakaki T, Ohta M, Inouye K. Sawada N, et al. Among authors: sakaki t. Biochem Biophys Res Commun. 2000 Jul 14;273(3):977-84. doi: 10.1006/bbrc.2000.3050. Biochem Biophys Res Commun. 2000. PMID: 10891358
Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24.
Sakaki T, Sawada N, Komai K, Shiozawa S, Yamada S, Yamamoto K, Ohyama Y, Inouye K. Sakaki T, et al. Eur J Biochem. 2000 Oct;267(20):6158-65. doi: 10.1046/j.1432-1327.2000.01680.x. Eur J Biochem. 2000. PMID: 11012668 Free article.
Human CYP24 demonstrated a remarkable metabolism consisting of both C-23 and C-24 hydroxylation pathways towards both 25(OH)D3 and 1alpha,25(OH)2D3, whereas rat CYP24 showed almost no C-23 hydroxylation pathway [Sakaki, T. Sawada, N. Nonaka, Y. Ohyama, Y. & Inou …
Human CYP24 demonstrated a remarkable metabolism consisting of both C-23 and C-24 hydroxylation pathways towards both 25(OH)D3 and 1alpha,25 …
Structure-function analysis of CYP27B1 and CYP27A1. Studies on mutants from patients with vitamin D-dependent rickets type I (VDDR-I) and cerebrotendinous xanthomatosis (CTX).
Sawada N, Sakaki T, Kitanaka S, Kato S, Inouye K. Sawada N, et al. Among authors: sakaki t. Eur J Biochem. 2001 Dec;268(24):6607-15. doi: 10.1046/j.0014-2956.2001.02615.x. Eur J Biochem. 2001. PMID: 11737215 Free article.
We have determined eight types of missense mutants of CYP27B1 from Japanese vitamin D-dependent rickets type I (VDDR-I) patients [Kitanaka, S., Takeyama, K., Murayama, A., Sato, T., Okumura, K., Nogami, M., Hasegawa, Y., Niimi, H., Yanagisawa, J., Tanaka, T. & K …
We have determined eight types of missense mutants of CYP27B1 from Japanese vitamin D-dependent rickets type I (VDDR-I) patients [Kitanaka, …
C-3 epimerization of vitamin D3 metabolites and further metabolism of C-3 epimers: 25-hydroxyvitamin D3 is metabolized to 3-epi-25-hydroxyvitamin D3 and subsequently metabolized through C-1alpha or C-24 hydroxylation.
Kamao M, Tatematsu S, Hatakeyama S, Sakaki T, Sawada N, Inouye K, Ozono K, Kubodera N, Reddy GS, Okano T. Kamao M, et al. Among authors: sakaki t. J Biol Chem. 2004 Apr 16;279(16):15897-907. doi: 10.1074/jbc.M311473200. Epub 2004 Feb 2. J Biol Chem. 2004. PMID: 14757768 Free article.
703 results