Singh K - Search Results

1

Synthesis and biological characterisation of ester and amide derivatives of fusidic acid as antiplasmodial agents.

Espinoza-Moraga M, Singh K, Njoroge M, Kaur G, Okombo J, De Kock C, Smith PJ, Wittlin S, Chibale K. Espinoza-Moraga M, et al. Among authors: singh k. Bioorg Med Chem Lett. 2017 Feb 1;27(3):658-661. doi: 10.1016/j.bmcl.2016.11.077. Epub 2016 Nov 25. Bioorg Med Chem Lett. 2017. PMID: 28012840 Free article.

2

Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.

Singh K, Okombo J, Brunschwig C, Ndubi F, Barnard L, Wilkinson C, Njogu PM, Njoroge M, Laing L, Machado M, Prudêncio M, Reader J, Botha M, Nondaba S, Birkholtz LM, Lauterbach S, Churchyard A, Coetzer TL, Burrows JN, Yeates C, Denti P, Wiesner L, Egan TJ, Wittlin S, Chibale K. Singh K, et al. J Med Chem. 2017 Feb 23;60(4):1432-1448. doi: 10.1021/acs.jmedchem.6b01641. Epub 2017 Feb 7. J Med Chem. 2017. PMID: 28094524

3

Antimalarial Pyrido[1,2- a]benzimidazole Derivatives with Mannich Base Side Chains: Synthesis, Pharmacological Evaluation, and Reactive Metabolite Trapping Studies.

Okombo J, Brunschwig C, Singh K, Dziwornu GA, Barnard L, Njoroge M, Wittlin S, Chibale K. Okombo J, et al. Among authors: singh k. ACS Infect Dis. 2019 Mar 8;5(3):372-384. doi: 10.1021/acsinfecdis.8b00279. Epub 2019 Jan 17. ACS Infect Dis. 2019. PMID: 30608648

4

Structure-activity relationship analyses of fusidic acid derivatives highlight crucial role of the C-21 carboxylic acid moiety to its anti-mycobacterial activity.

Singh K, Kaur G, Shanika PS, Dziwornu GA, Okombo J, Chibale K. Singh K, et al. Bioorg Med Chem. 2020 Jul 1;28(13):115530. doi: 10.1016/j.bmc.2020.115530. Epub 2020 Apr 25. Bioorg Med Chem. 2020. PMID: 32362386

5

Synthesis of new verapamil analogues and their evaluation in combination with rifampicin against Mycobacterium tuberculosis and molecular docking studies in the binding site of efflux protein Rv1258c.

Singh K, Kumar M, Pavadai E, Naran K, Warner DF, Ruminski PG, Chibale K. Singh K, et al. Bioorg Med Chem Lett. 2014 Jul 15;24(14):2985-90. doi: 10.1016/j.bmcl.2014.05.022. Epub 2014 May 16. Bioorg Med Chem Lett. 2014. PMID: 24894561

6

Antischistosomal Activity of Pyrido[1,2-a]benzimidazole Derivatives and Correlation with Inhibition of β-Hematin Formation.

Okombo J, Singh K, Mayoka G, Ndubi F, Barnard L, Njogu PM, Njoroge M, Gibhard L, Brunschwig C, Vargas M, Keiser J, Egan TJ, Chibale K. Okombo J, et al. Among authors: singh k. ACS Infect Dis. 2017 Jun 9;3(6):411-420. doi: 10.1021/acsinfecdis.6b00205. Epub 2017 May 3. ACS Infect Dis. 2017. PMID: 28440625

7

Reversed isoniazids: Design, synthesis and evaluation against Mycobacterium tuberculosis.

Kumar M, Singh K, Ngwane AH, Hamzabegovic F, Abate G, Baker B, Wiid I, Hoft DF, Ruminski P, Chibale K. Kumar M, et al. Among authors: singh k. Bioorg Med Chem. 2018 Feb 15;26(4):833-844. doi: 10.1016/j.bmc.2017.12.047. Epub 2017 Dec 29. Bioorg Med Chem. 2018. PMID: 29373270

8

Design, Synthesis, and Evaluation of Novel Hybrid Efflux Pump Inhibitors for Use against Mycobacterium tuberculosis.

Kumar M, Singh K, Naran K, Hamzabegovic F, Hoft DF, Warner DF, Ruminski P, Abate G, Chibale K. Kumar M, et al. Among authors: singh k. ACS Infect Dis. 2016 Oct 14;2(10):714-725. doi: 10.1021/acsinfecdis.6b00111. Epub 2016 Sep 6. ACS Infect Dis. 2016. PMID: 27737555

9

Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity.

Govender P, Müller R, Singh K, Reddy V, Eyermann CJ, Fienberg S, Ghorpade SR, Koekemoer L, Myrick A, Schnappinger D, Engelhart C, Meshanni J, Byl JAW, Osheroff N, Singh V, Chibale K, Basarab GS. Govender P, et al. Among authors: singh k, singh v. J Med Chem. 2022 May 12;65(9):6903-6925. doi: 10.1021/acs.jmedchem.2c00266. Epub 2022 May 2. J Med Chem. 2022. PMID: 35500229 Free PMC article.

10

Facile transformation of Biginelli pyrimidin-2(1H)-ones to pyrimidines. In vitro evaluation as inhibitors of Mycobacterium tuberculosis and modulators of cytostatic activity.

Singh K, Singh K, Wan B, Franzblau S, Chibale K, Balzarini J. Singh K, et al. Eur J Med Chem. 2011 Jun;46(6):2290-4. doi: 10.1016/j.ejmech.2011.03.010. Epub 2011 Mar 15. Eur J Med Chem. 2011. PMID: 21450375

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