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The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors.
J Med Chem. 2017 Feb 9;60(3):1105-1125. doi: 10.1021/acs.jmedchem.6b01496. Epub 2016 Dec 21.
J Med Chem. 2017.
PMID: 28001399
Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators.
Huang X, Shaffer PL, Ayube S, Bregman H, Chen H, Lehto SG, Luther JA, Matson DJ, McDonough SI, Michelsen K, Plant MH, Schneider S, Simard JR, Teffera Y, Yi S, Zhang M, DiMauro EF, Gingras J.
Huang X, et al. Among authors: ayube s.
Nat Struct Mol Biol. 2017 Feb;24(2):108-113. doi: 10.1038/nsmb.3329. Epub 2016 Dec 19.
Nat Struct Mol Biol. 2017.
PMID: 27991902
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In-column dilution: Improving volume loadability in reverse phase gradient chromatography through the use of a silica pre-column.
Miller L, Ayube SJ.
Miller L, et al. Among authors: ayube sj.
J Chromatogr A. 2020 May 10;1618:460897. doi: 10.1016/j.chroma.2020.460897. Epub 2020 Jan 23.
J Chromatogr A. 2020.
PMID: 32007218
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