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Page 1
Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).
Grieben M, Pike AC, Shintre CA, Venturi E, El-Ajouz S, Tessitore A, Shrestha L, Mukhopadhyay S, Mahajan P, Chalk R, Burgess-Brown NA, Sitsapesan R, Huiskonen JT, Carpenter EP. Grieben M, et al. Among authors: pike ac. Nat Struct Mol Biol. 2017 Feb;24(2):114-122. doi: 10.1038/nsmb.3343. Epub 2016 Dec 19. Nat Struct Mol Biol. 2017. PMID: 27991905
The structural basis of ZMPSTE24-dependent laminopathies.
Quigley A, Dong YY, Pike AC, Dong L, Shrestha L, Berridge G, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, von Delft F, Bullock AN, Burgess-Brown NA, Carpenter EP. Quigley A, et al. Among authors: pike ac. Science. 2013 Mar 29;339(6127):1604-7. doi: 10.1126/science.1231513. Science. 2013. PMID: 23539603
Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.
Shintre CA, Pike AC, Li Q, Kim JI, Barr AJ, Goubin S, Shrestha L, Yang J, Berridge G, Ross J, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, Marsden BD, von Delft F, Bullock AN, Gileadi O, Burgess-Brown NA, Carpenter EP. Shintre CA, et al. Among authors: pike ac. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9710-5. doi: 10.1073/pnas.1217042110. Epub 2013 May 28. Proc Natl Acad Sci U S A. 2013. PMID: 23716676 Free PMC article.
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP. Dong YY, et al. Among authors: pike ac. Science. 2015 Mar 13;347(6227):1256-9. doi: 10.1126/science.1261512. Science. 2015. PMID: 25766236 Free PMC article.
An overview of heavy-atom derivatization of protein crystals.
Pike AC, Garman EF, Krojer T, von Delft F, Carpenter EP. Pike AC, et al. Acta Crystallogr D Struct Biol. 2016 Mar;72(Pt 3):303-18. doi: 10.1107/S2059798316000401. Epub 2016 Mar 1. Acta Crystallogr D Struct Biol. 2016. PMID: 26960118 Free PMC article. Review.
Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2.
Wilkes M, Madej MG, Kreuter L, Rhinow D, Heinz V, De Sanctis S, Ruppel S, Richter RM, Joos F, Grieben M, Pike AC, Huiskonen JT, Carpenter EP, Kühlbrandt W, Witzgall R, Ziegler C. Wilkes M, et al. Among authors: pike ac. Nat Struct Mol Biol. 2017 Feb;24(2):123-130. doi: 10.1038/nsmb.3357. Epub 2017 Jan 16. Nat Struct Mol Biol. 2017. PMID: 28092368
Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.
Dong YY, Wang H, Pike ACW, Cochrane SA, Hamedzadeh S, Wyszyński FJ, Bushell SR, Royer SF, Widdick DA, Sajid A, Boshoff HI, Park Y, Lucas R, Liu WM, Lee SS, Machida T, Minall L, Mehmood S, Belaya K, Liu WW, Chu A, Shrestha L, Mukhopadhyay SMM, Strain-Damerell C, Chalk R, Burgess-Brown NA, Bibb MJ, Barry Iii CE, Robinson CV, Beeson D, Davis BG, Carpenter EP. Dong YY, et al. Cell. 2018 Nov 1;175(4):1045-1058.e16. doi: 10.1016/j.cell.2018.10.037. Cell. 2018. PMID: 30388443 Free PMC article.
A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels.
Schewe M, Sun H, Mert Ü, Mackenzie A, Pike ACW, Schulz F, Constantin C, Vowinkel KS, Conrad LJ, Kiper AK, Gonzalez W, Musinszki M, Tegtmeier M, Pryde DC, Belabed H, Nazare M, de Groot BL, Decher N, Fakler B, Carpenter EP, Tucker SJ, Baukrowitz T. Schewe M, et al. Science. 2019 Feb 22;363(6429):875-880. doi: 10.1126/science.aav0569. Science. 2019. PMID: 30792303 Free PMC article.
67 results