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Page 1
Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).
Grieben M, Pike AC, Shintre CA, Venturi E, El-Ajouz S, Tessitore A, Shrestha L, Mukhopadhyay S, Mahajan P, Chalk R, Burgess-Brown NA, Sitsapesan R, Huiskonen JT, Carpenter EP. Grieben M, et al. Nat Struct Mol Biol. 2017 Feb;24(2):114-122. doi: 10.1038/nsmb.3343. Epub 2016 Dec 19. Nat Struct Mol Biol. 2017. PMID: 27991905
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP. Dong YY, et al. Among authors: grieben m. Science. 2015 Mar 13;347(6227):1256-9. doi: 10.1126/science.1261512. Science. 2015. PMID: 25766236 Free PMC article.
The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions.
Fasciani I, Petragnano F, Wang Z, Edwards R, Telugu N, Pietrantoni I, Zabel U, Zauber H, Grieben M, Terzenidou ME, Di Gregorio J, Pellegrini C, Santini S Jr, Taddei AR, Pohl B, Aringhieri S, Carli M, Aloisi G, Marampon F, Charlesworth E, Roman A, Diecke S, Flati V, Giorgi F, Amicarelli F, Tobin AB, Scarselli M, Tokatlidis K, Rossi M, Lohse MJ, Annibale P, Maggio R. Fasciani I, et al. Among authors: grieben m. PLoS Biol. 2024 Apr 29;22(4):e3002582. doi: 10.1371/journal.pbio.3002582. eCollection 2024 Apr. PLoS Biol. 2024. PMID: 38683874 Free PMC article.
Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2.
Wilkes M, Madej MG, Kreuter L, Rhinow D, Heinz V, De Sanctis S, Ruppel S, Richter RM, Joos F, Grieben M, Pike AC, Huiskonen JT, Carpenter EP, Kühlbrandt W, Witzgall R, Ziegler C. Wilkes M, et al. Among authors: grieben m. Nat Struct Mol Biol. 2017 Feb;24(2):123-130. doi: 10.1038/nsmb.3357. Epub 2017 Jan 16. Nat Struct Mol Biol. 2017. PMID: 28092368