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NQO1 inhibits proteasome-mediated degradation of HIF-1α.
Oh ET, Kim JW, Kim JM, Kim SJ, Lee JS, Hong SS, Goodwin J, Ruthenborg RJ, Jung MG, Lee HJ, Lee CH, Park ES, Kim C, Park HJ. Oh ET, et al. Among authors: ruthenborg rj. Nat Commun. 2016 Dec 14;7:13593. doi: 10.1038/ncomms13593. Nat Commun. 2016. PMID: 27966538 Free PMC article.
The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition.
Goodwin J, Neugent ML, Lee SY, Choe JH, Choi H, Jenkins DMR, Ruthenborg RJ, Robinson MW, Jeong JY, Wake M, Abe H, Takeda N, Endo H, Inoue M, Xuan Z, Yoo H, Chen M, Ahn JM, Minna JD, Helke KL, Singh PK, Shackelford DB, Kim JW. Goodwin J, et al. Among authors: ruthenborg rj. Nat Commun. 2017 May 26;8:15503. doi: 10.1038/ncomms15503. Nat Commun. 2017. PMID: 28548087 Free PMC article.