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NQO1 inhibits proteasome-mediated degradation of HIF-1α.
Oh ET, Kim JW, Kim JM, Kim SJ, Lee JS, Hong SS, Goodwin J, Ruthenborg RJ, Jung MG, Lee HJ, Lee CH, Park ES, Kim C, Park HJ. Oh ET, et al. Among authors: kim jm, kim c, kim sj, kim jw. Nat Commun. 2016 Dec 14;7:13593. doi: 10.1038/ncomms13593. Nat Commun. 2016. PMID: 27966538 Free PMC article.
The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition.
Goodwin J, Neugent ML, Lee SY, Choe JH, Choi H, Jenkins DMR, Ruthenborg RJ, Robinson MW, Jeong JY, Wake M, Abe H, Takeda N, Endo H, Inoue M, Xuan Z, Yoo H, Chen M, Ahn JM, Minna JD, Helke KL, Singh PK, Shackelford DB, Kim JW. Goodwin J, et al. Among authors: kim jw. Nat Commun. 2017 May 26;8:15503. doi: 10.1038/ncomms15503. Nat Commun. 2017. PMID: 28548087 Free PMC article.
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.
Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins DM, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I. Semba H, et al. Among authors: kim jw. Nat Commun. 2016 May 18;7:11635. doi: 10.1038/ncomms11635. Nat Commun. 2016. PMID: 27189088 Free PMC article.
A New Perspective on the Heterogeneity of Cancer Glycolysis.
Neugent ML, Goodwin J, Sankaranarayanan I, Yetkin CE, Hsieh MH, Kim JW. Neugent ML, et al. Among authors: kim jw. Biomol Ther (Seoul). 2018 Jan 1;26(1):10-18. doi: 10.4062/biomolther.2017.210. Biomol Ther (Seoul). 2018. PMID: 29212302 Free PMC article. Review.
Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis.
Goodwin J, Choi H, Hsieh MH, Neugent ML, Ahn JM, Hayenga HN, Singh PK, Shackelford DB, Lee IK, Shulaev V, Dhar S, Takeda N, Kim JW. Goodwin J, et al. Among authors: kim jw. Am J Respir Cell Mol Biol. 2018 Feb;58(2):216-231. doi: 10.1165/rcmb.2016-0186OC. Am J Respir Cell Mol Biol. 2018. PMID: 28915065 Free PMC article.
Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M.
Abe H, Takeda N, Isagawa T, Semba H, Nishimura S, Morioka MS, Nakagama Y, Sato T, Soma K, Koyama K, Wake M, Katoh M, Asagiri M, Neugent ML, Kim JW, Stockmann C, Yonezawa T, Inuzuka R, Hirota Y, Maemura K, Yamashita T, Otsu K, Manabe I, Nagai R, Komuro I. Abe H, et al. Among authors: kim jw. Nat Commun. 2019 Jun 27;10(1):2824. doi: 10.1038/s41467-019-10859-w. Nat Commun. 2019. PMID: 31249305 Free PMC article.
Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype.
Min BK, Park S, Kang HJ, Kim DW, Ham HJ, Ha CM, Choi BJ, Lee JY, Oh CJ, Yoo EK, Kim HE, Kim BG, Jeon JH, Hyeon DY, Hwang D, Kim YH, Lee CH, Lee T, Kim JW, Choi YK, Park KG, Chawla A, Lee J, Harris RA, Lee IK. Min BK, et al. Among authors: kim yh, kim dw, kim bg, kim he, kim jw. Front Immunol. 2019 May 7;10:944. doi: 10.3389/fimmu.2019.00944. eCollection 2019. Front Immunol. 2019. PMID: 31134063 Free PMC article.
8,742 results