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Enhancers and super-enhancers have an equivalent regulatory role in embryonic stem cells through regulation of single or multiple genes.
Genome Res. 2017 Feb;27(2):246-258. doi: 10.1101/gr.210930.116. Epub 2016 Nov 28.
Genome Res. 2017.
PMID: 27895109
Free PMC article.
Transcriptional regulation and chromatin architecture maintenance are decoupled functions at the Sox2 locus.
Taylor T, Sikorska N, Shchuka VM, Chahar S, Ji C, Macpherson NN, Moorthy SD, de Kort MAC, Mullany S, Khader N, Gillespie ZE, Langroudi L, Tobias IC, Lenstra TL, Mitchell JA, Sexton T.
Taylor T, et al. Among authors: shchuka vm.
Genes Dev. 2022 Jun 1;36(11-12):699-717. doi: 10.1101/gad.349489.122. Epub 2022 Jun 16.
Genes Dev. 2022.
PMID: 35710138
Free PMC article.
Item in Clipboard
Chromatin Dynamics in Lineage Commitment and Cellular Reprogramming.
Shchuka VM, Malek-Gilani N, Singh G, Langroudi L, Dhaliwal NK, Moorthy SD, Davidson S, Macpherson NN, Mitchell JA.
Shchuka VM, et al.
Genes (Basel). 2015 Jul 17;6(3):641-61. doi: 10.3390/genes6030641.
Genes (Basel). 2015.
PMID: 26193323
Free PMC article.
Review.
Item in Clipboard
Transcriptional control of parturition: insights from gene regulation studies in the myometrium.
Khader N, Shchuka VM, Shynlova O, Mitchell JA.
Khader N, et al. Among authors: shchuka vm.
Mol Hum Reprod. 2021 May 8;27(5):gaab024. doi: 10.1093/molehr/gaab024.
Mol Hum Reprod. 2021.
PMID: 33823545
Free PMC article.
Review.
Item in Clipboard
The pregnant myometrium is epigenetically activated at contractility-driving gene loci prior to the onset of labor in mice.
Shchuka VM, Abatti LE, Hou H, Khader N, Dorogin A, Wilson MD, Shynlova O, Mitchell JA.
Shchuka VM, et al.
PLoS Biol. 2020 Jul 15;18(7):e3000710. doi: 10.1371/journal.pbio.3000710. eCollection 2020 Jul.
PLoS Biol. 2020.
PMID: 32667910
Free PMC article.
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SOX4 exerts contrasting regulatory effects on labor-associated gene promoters in myometrial cells.
Khader N, Shchuka VM, Dorogin A, Shynlova O, Mitchell JA.
Khader N, et al. Among authors: shchuka vm.
PLoS One. 2024 Apr 18;19(4):e0297847. doi: 10.1371/journal.pone.0297847. eCollection 2024.
PLoS One. 2024.
PMID: 38635533
Free PMC article.
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Competition between transcription and loop extrusion modulates promoter and enhancer dynamics.
Platania A, Erb C, Barbieri M, Molcrette B, Grandgirard E, de Kort MA, Meaburn K, Taylor T, Shchuka VM, Kocanova S, Oliveira GM, Mitchell JA, Soutoglou E, Lenstra TL, Molina N, Papantonis A, Bystricky K, Sexton T.
Platania A, et al. Among authors: shchuka vm.
bioRxiv [Preprint]. 2023 Apr 26:2023.04.25.538222. doi: 10.1101/2023.04.25.538222.
bioRxiv. 2023.
PMID: 37162887
Free PMC article.
Preprint.
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MYB and ELF3 differentially modulate labor-inducing gene expression in myometrial cells.
Shchuka VM, Khader N, Dorogin A, Shynlova O, Mitchell JA.
Shchuka VM, et al.
PLoS One. 2023 Jan 3;18(1):e0271081. doi: 10.1371/journal.pone.0271081. eCollection 2023.
PLoS One. 2023.
PMID: 36595497
Free PMC article.
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