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The isolation and synthesis of a novel benzofuran compound from Tephrosia purpurea, and the synthesis of several related derivatives, which suppress histamine H1 receptor gene expression.
Shill MC, Das AK, Itou T, Karmakar S, Mukherjee PK, Mizuguchi H, Kashiwada Y, Fukui H, Nemoto H. Shill MC, et al. Among authors: nemoto h. Bioorg Med Chem. 2015 Nov 1;23(21):6869-74. doi: 10.1016/j.bmc.2015.09.049. Epub 2015 Oct 21. Bioorg Med Chem. 2015. PMID: 26476665
Maackiain is a novel antiallergic compound that suppresses transcriptional upregulation of the histamine H1 receptor and interleukin-4 genes.
Mizuguchi H, Nariai Y, Kato S, Nakano T, Kanayama T, Kashiwada Y, Nemoto H, Kawazoe K, Takaishi Y, Kitamura Y, Takeda N, Fukui H. Mizuguchi H, et al. Among authors: nemoto h. Pharmacol Res Perspect. 2015 Oct;3(5):e00166. doi: 10.1002/prp2.166. Epub 2015 Aug 10. Pharmacol Res Perspect. 2015. PMID: 26516579 Free PMC article.
A novel benzofuran, 4-methoxybenzofuran-5-carboxamide, from Tephrosia purpurea suppressed histamine H1 receptor gene expression through a protein kinase C-δ-dependent signaling pathway.
Shill MC, Mizuguchi H, Karmakar S, Kadota T, Mukherjee PK, Kitamura Y, Kashiwada Y, Nemoto H, Takeda N, Fukui H. Shill MC, et al. Among authors: nemoto h. Int Immunopharmacol. 2016 Jan;30:18-26. doi: 10.1016/j.intimp.2015.11.021. Epub 2015 Nov 24. Int Immunopharmacol. 2016. PMID: 26619301
Disruption of Heat Shock Protein 90 (Hsp90)-Protein Kinase Cδ (PKCδ) Interaction by (-)-Maackiain Suppresses Histamine H1 Receptor Gene Transcription in HeLa Cells.
Nariai Y, Mizuguchi H, Ogasawara T, Nagai H, Sasaki Y, Okamoto Y, Yoshimura Y, Kitamura Y, Nemoto H, Takeda N, Fukui H. Nariai Y, et al. Among authors: nemoto h. J Biol Chem. 2015 Nov 6;290(45):27393-27402. doi: 10.1074/jbc.M115.657023. Epub 2015 Sep 21. J Biol Chem. 2015. PMID: 26391399 Free PMC article.
8-Prenylnaringenin promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice.
Mukai R, Horikawa H, Lin PY, Tsukumo N, Nikawa T, Kawamura T, Nemoto H, Terao J. Mukai R, et al. Among authors: nemoto h. Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1;311(6):R1022-R1031. doi: 10.1152/ajpregu.00521.2015. Epub 2016 Sep 14. Am J Physiol Regul Integr Comp Physiol. 2016. PMID: 27629889 Free article.
Synthesis of paclitaxel-BGL conjugates.
Nemoto H, Katagiri A, Kamiya M, Kawamura T, Matsushita T, Matsumura K, Itou T, Hattori H, Tamaki M, Ishizawa K, Miyamoto L, Abe S, Tsuchiya K. Nemoto H, et al. Bioorg Med Chem. 2012 Sep 15;20(18):5559-67. doi: 10.1016/j.bmc.2012.07.031. Epub 2012 Jul 25. Bioorg Med Chem. 2012. PMID: 22892212
450 results