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Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins.
Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS. Cil O, et al. Among authors: donowitz m. FASEB J. 2017 Feb;31(2):751-760. doi: 10.1096/fj.201600891R. Epub 2016 Nov 8. FASEB J. 2017. PMID: 27871064 Free PMC article.
These studies support the potential utility of (R)-BPO-27 for therapy of CFTR-mediated secretory diarrheas.-Cil, O., Phuan, P.-W., Gillespie, A. M., Lee, S., Tradtrantip, L., Yin, J., Tse, M., Zachos, N. C., Lin, R., Donowitz, M., Verkman, A. ...
These studies support the potential utility of (R)-BPO-27 for therapy of CFTR-mediated secretory diarrheas.-Cil, O., Phuan, P.-W., Gillespie …
Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation.
Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJV, Donowitz M, Kurth MJ, Verkman AS. Cil O, et al. Among authors: donowitz m. Transl Res. 2017 Apr;182:14-26.e4. doi: 10.1016/j.trsl.2016.10.003. Epub 2016 Oct 15. Transl Res. 2017. PMID: 27815136 Free PMC article.
Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea.
Duan T, Cil O, Tse CM, Sarker R, Lin R, Donowitz M, Verkman AS. Duan T, et al. Among authors: donowitz m. FASEB J. 2019 Oct;33(10):10924-10934. doi: 10.1096/fj.201901166R. Epub 2019 Jul 3. FASEB J. 2019. PMID: 31268738 Free PMC article.
These results implicate CFTR activation in the colon as a major prosecretory mechanism of CDCA, a bile acid implicated in BAD, and support the potential therapeutic efficacy of CFTR inhibition in bile acid-associated diarrheas.-Duan, T., Cil, O., Tse, C. M., Sarker, R., Li …
These results implicate CFTR activation in the colon as a major prosecretory mechanism of CDCA, a bile acid implicated in BAD, and support t …
Secretory diarrhoea: mechanisms and emerging therapies.
Thiagarajah JR, Donowitz M, Verkman AS. Thiagarajah JR, et al. Among authors: donowitz m. Nat Rev Gastroenterol Hepatol. 2015 Aug;12(8):446-57. doi: 10.1038/nrgastro.2015.111. Epub 2015 Jun 30. Nat Rev Gastroenterol Hepatol. 2015. PMID: 26122478 Free PMC article. Review.
Molecular physiology of intestinal Na+/H+ exchange.
Zachos NC, Tse M, Donowitz M. Zachos NC, et al. Among authors: donowitz m. Annu Rev Physiol. 2005;67:411-43. doi: 10.1146/annurev.physiol.67.031103.153004. Annu Rev Physiol. 2005. PMID: 15709964 Review.
322 results