Cuyckens F - Search Results

1

In vitro and physiologically-based pharmacokinetic based assessment of drug-drug interaction potential of canagliflozin.

Mamidi RNVS, Dallas S, Sensenhauser C, Lim HK, Scheers E, Verboven P, Cuyckens F, Leclercq L, Evans DC, Kelley MF, Johnson MD, Snoeys J. Mamidi RNVS, et al. Among authors: cuyckens f. Br J Clin Pharmacol. 2017 May;83(5):1082-1096. doi: 10.1111/bcp.13186. Epub 2016 Dec 20. Br J Clin Pharmacol. 2017. PMID: 27862160 Free PMC article.

2

Improved liquid chromatography-Online radioactivity detection for metabolite profiling.

Cuyckens F, Koppen V, Kembuegler R, Leclercq L. Cuyckens F, et al. J Chromatogr A. 2008 Oct 31;1209(1-2):128-35. doi: 10.1016/j.chroma.2008.09.002. Epub 2008 Sep 5. J Chromatogr A. 2008. PMID: 18817918

3

IsoScore: automated localization of biotransformations by mass spectrometry using product ion scoring of virtual regioisomers.

Leclercq L, Mortishire-Smith RJ, Huisman M, Cuyckens F, Hartshorn MJ, Hill A. Leclercq L, et al. Among authors: cuyckens f. Rapid Commun Mass Spectrom. 2009 Jan;23(1):39-50. doi: 10.1002/rcm.3854. Rapid Commun Mass Spectrom. 2009. PMID: 19051234

4

Extracting metabolite ions out of a matrix background by combined mass defect, neutral loss and isotope filtration.

Cuyckens F, Hurkmans R, Castro-Perez JM, Leclercq L, Mortishire-Smith RJ. Cuyckens F, et al. Rapid Commun Mass Spectrom. 2009 Jan;23(2):327-32. doi: 10.1002/rcm.3881. Rapid Commun Mass Spectrom. 2009. PMID: 19089853

5

Which human metabolites have we MIST? Retrospective analysis, practical aspects, and perspectives for metabolite identification and quantification in pharmaceutical development.

Leclercq L, Cuyckens F, Mannens GS, de Vries R, Timmerman P, Evans DC. Leclercq L, et al. Among authors: cuyckens f. Chem Res Toxicol. 2009 Feb;22(2):280-93. doi: 10.1021/tx800432c. Chem Res Toxicol. 2009. PMID: 19183054 Review.

6

Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.

Parker MH, Smith-Swintosky VL, McComsey DF, Huang Y, Brenneman D, Klein B, Malatynska E, White HS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Iannucci R, Leclercq L, Cuyckens F, Reitz AB, Maryanoff BE. Parker MH, et al. Among authors: cuyckens f. J Med Chem. 2009 Dec 10;52(23):7528-36. doi: 10.1021/jm801432r. J Med Chem. 2009. PMID: 19388676

7

In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping.

Vermeir M, Hemeryck A, Cuyckens F, Francesch A, Bockx M, Van Houdt J, Steemans K, Mannens G, Avilés P, De Coster R. Vermeir M, et al. Among authors: cuyckens f. Biochem Pharmacol. 2009 May 15;77(10):1642-54. doi: 10.1016/j.bcp.2009.02.020. Epub 2009 Mar 10. Biochem Pharmacol. 2009. PMID: 19426702

8

Use of relative 12C/14C isotope ratios to estimate metabolite concentrations in the absence of authentic standards.

Cuyckens F, Pauwels N, Koppen V, Leclercq L. Cuyckens F, et al. Bioanalysis. 2012 Jan;4(2):143-56. doi: 10.4155/bio.11.302. Bioanalysis. 2012. PMID: 22250797

9

Metabolism and excretion of canagliflozin in mice, rats, dogs, and humans.

Mamidi RN, Cuyckens F, Chen J, Scheers E, Kalamaridis D, Lin R, Silva J, Sha S, Evans DC, Kelley MF, Devineni D, Johnson MD, Lim HK. Mamidi RN, et al. Among authors: cuyckens f. Drug Metab Dispos. 2014 May;42(5):903-16. doi: 10.1124/dmd.113.056440. Epub 2014 Feb 25. Drug Metab Dispos. 2014. PMID: 24568888 Clinical Trial.

10

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data.

T'jollyn H, Snoeys J, Colin P, Van Bocxlaer J, Annaert P, Cuyckens F, Vermeulen A, Van Peer A, Allegaert K, Mannens G, Boussery K. T'jollyn H, et al. Among authors: cuyckens f. Pharm Res. 2015 Jan;32(1):260-74. doi: 10.1007/s11095-014-1460-x. Epub 2014 Jul 22. Pharm Res. 2015. PMID: 25048637

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