Orr MT - Search Results

1

Adsorption of a synthetic TLR7/8 ligand to aluminum oxyhydroxide for enhanced vaccine adjuvant activity: A formulation approach.

Fox CB, Orr MT, Van Hoeven N, Parker SC, Mikasa TJ, Phan T, Beebe EA, Nana GI, Joshi SW, Tomai MA, Elvecrog J, Fouts TR, Reed SG. Fox CB, et al. Among authors: orr mt. J Control Release. 2016 Dec 28;244(Pt A):98-107. doi: 10.1016/j.jconrel.2016.11.011. Epub 2016 Nov 12. J Control Release. 2016. PMID: 27847326 Free PMC article.

2

Therapeutic immunization against Mycobacterium tuberculosis is an effective adjunct to antibiotic treatment.

Coler RN, Bertholet S, Pine SO, Orr MT, Reese V, Windish HP, Davis C, Kahn M, Baldwin SL, Reed SG. Coler RN, et al. Among authors: orr mt. J Infect Dis. 2013 Apr 15;207(8):1242-52. doi: 10.1093/infdis/jis425. Epub 2012 Aug 13. J Infect Dis. 2013. PMID: 22891286 Free PMC article.

3

MyD88 and TRIF synergistic interaction is required for TH1-cell polarization with a synthetic TLR4 agonist adjuvant.

Orr MT, Duthie MS, Windish HP, Lucas EA, Guderian JA, Hudson TE, Shaverdian N, O'Donnell J, Desbien AL, Reed SG, Coler RN. Orr MT, et al. Eur J Immunol. 2013 Sep;43(9):2398-408. doi: 10.1002/eji.201243124. Epub 2013 Jul 3. Eur J Immunol. 2013. PMID: 23716300 Free PMC article.

4

Protection against tuberculosis with homologous or heterologous protein/vector vaccine approaches is not dependent on CD8+ T cells.

Baldwin SL, Ching LK, Pine SO, Moutaftsi M, Lucas E, Vallur A, Orr MT, Bertholet S, Reed SG, Coler RN. Baldwin SL, et al. Among authors: orr mt. J Immunol. 2013 Sep 1;191(5):2514-2525. doi: 10.4049/jimmunol.1301161. Epub 2013 Jul 31. J Immunol. 2013. PMID: 23904160 Free PMC article.

5

Adjuvant formulation structure and composition are critical for the development of an effective vaccine against tuberculosis.

Orr MT, Fox CB, Baldwin SL, Sivananthan SJ, Lucas E, Lin S, Phan T, Moon JJ, Vedvick TS, Reed SG, Coler RN. Orr MT, et al. J Control Release. 2013 Nov 28;172(1):190-200. doi: 10.1016/j.jconrel.2013.07.030. Epub 2013 Aug 9. J Control Release. 2013. PMID: 23933525 Free PMC article.

6

Key roles of adjuvants in modern vaccines.

Reed SG, Orr MT, Fox CB. Reed SG, et al. Among authors: orr mt. Nat Med. 2013 Dec;19(12):1597-608. doi: 10.1038/nm.3409. Epub 2013 Dec 5. Nat Med. 2013. PMID: 24309663 Review.

7

Elimination of the cold-chain dependence of a nanoemulsion adjuvanted vaccine against tuberculosis by lyophilization.

Orr MT, Kramer RM, Barnes L 5th, Dowling QM, Desbien AL, Beebe EA, Laurance JD, Fox CB, Reed SG, Coler RN, Vedvick TS. Orr MT, et al. J Control Release. 2014 Mar 10;177:20-6. doi: 10.1016/j.jconrel.2013.12.025. Epub 2013 Dec 29. J Control Release. 2014. PMID: 24382398 Free PMC article.

8

A dual TLR agonist adjuvant enhances the immunogenicity and protective efficacy of the tuberculosis vaccine antigen ID93.

Orr MT, Beebe EA, Hudson TE, Moon JJ, Fox CB, Reed SG, Coler RN. Orr MT, et al. PLoS One. 2014 Jan 3;9(1):e83884. doi: 10.1371/journal.pone.0083884. eCollection 2014. PLoS One. 2014. PMID: 24404140 Free PMC article.

9

The ID93 tuberculosis vaccine candidate does not induce sensitivity to purified protein derivative.

Baldwin SL, Reese V, Granger B, Orr MT, Ireton GC, Coler RN, Reed SG. Baldwin SL, et al. Among authors: orr mt. Clin Vaccine Immunol. 2014 Sep;21(9):1309-13. doi: 10.1128/CVI.00372-14. Epub 2014 Jul 16. Clin Vaccine Immunol. 2014. PMID: 25030053 Free PMC article.

10

Immune subdominant antigens as vaccine candidates against Mycobacterium tuberculosis.

Orr MT, Ireton GC, Beebe EA, Huang PW, Reese VA, Argilla D, Coler RN, Reed SG. Orr MT, et al. J Immunol. 2014 Sep 15;193(6):2911-8. doi: 10.4049/jimmunol.1401103. Epub 2014 Aug 1. J Immunol. 2014. PMID: 25086172 Free PMC article.

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