Appleton KM - Search Results

1

Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma.

Haak AJ, Appleton KM, Lisabeth EM, Misek SA, Ji Y, Wade SM, Bell JL, Rockwell CE, Airik M, Krook MA, Larsen SD, Verhaegen M, Lawlor ER, Neubig RR. Haak AJ, et al. Among authors: appleton km. Mol Cancer Ther. 2017 Jan;16(1):193-204. doi: 10.1158/1535-7163.MCT-16-0482. Epub 2016 Nov 11. Mol Cancer Ther. 2017. PMID: 27837031 Free PMC article.

2

Rho-mediated signaling promotes BRAF inhibitor resistance in de-differentiated melanoma cells.

Misek SA, Appleton KM, Dexheimer TS, Lisabeth EM, Lo RS, Larsen SD, Gallo KA, Neubig RR. Misek SA, et al. Among authors: appleton km. Oncogene. 2020 Feb;39(7):1466-1483. doi: 10.1038/s41388-019-1074-1. Epub 2019 Oct 28. Oncogene. 2020. PMID: 31659259 Free PMC article.

3

Inhibition of the Myocardin-Related Transcription Factor Pathway Increases Efficacy of Trametinib in NRAS-Mutant Melanoma Cell Lines.

Appleton KM, Palsuledesai CC, Misek SA, Blake M, Zagorski J, Gallo KA, Dexheimer TS, Neubig RR. Appleton KM, et al. Cancers (Basel). 2021 Apr 22;13(9):2012. doi: 10.3390/cancers13092012. Cancers (Basel). 2021. PMID: 33921974 Free PMC article.

4

Suppression of GNAI2 message in ovarian cancer.

Raymond JR Jr, Appleton KM, Pierce JY, Peterson YK. Raymond JR Jr, et al. Among authors: appleton km. J Ovarian Res. 2014 Jan 14;7:6. doi: 10.1186/1757-2215-7-6. J Ovarian Res. 2014. PMID: 24423449 Free PMC article.

5

Emergent biological properties of arrestin pathway-selective biased agonism.

Appleton KM, Luttrell LM. Appleton KM, et al. J Recept Signal Transduct Res. 2013 Jun;33(3):153-61. doi: 10.3109/10799893.2013.769004. Epub 2013 Feb 28. J Recept Signal Transduct Res. 2013. PMID: 23448506

6

Development of inhibitors of heterotrimeric Gαi subunits.

Appleton KM, Bigham KJ, Lindsey CC, Hazard S, Lirjoni J, Parnham S, Hennig M, Peterson YK. Appleton KM, et al. Bioorg Med Chem. 2014 Jul 1;22(13):3423-34. doi: 10.1016/j.bmc.2014.04.035. Epub 2014 Apr 26. Bioorg Med Chem. 2014. PMID: 24818958 Free PMC article.

7

A high-content, live-cell, and real-time approach to the quantitation of ligand-induced β-Arrestin2 and Class A/Class B GPCR mobilization.

Leonard AP, Appleton KM, Luttrell LM, Peterson YK. Leonard AP, et al. Among authors: appleton km. Microsc Microanal. 2013 Feb;19(1):150-70. doi: 10.1017/S1431927612014067. Epub 2013 Jan 28. Microsc Microanal. 2013. PMID: 23351552 Free PMC article.

8

Biasing the parathyroid hormone receptor: relating in vitro ligand efficacy to in vivo biological activity.

Appleton KM, Lee MH, Alele C, Alele C, Luttrell DK, Peterson YK, Morinelli TA, Luttrell LM. Appleton KM, et al. Methods Enzymol. 2013;522:229-62. doi: 10.1016/B978-0-12-407865-9.00013-3. Methods Enzymol. 2013. PMID: 23374189

9

The arrestin-selective angiotensin AT1 receptor agonist [Sar1,Ile4,Ile8]-AngII negatively regulates bradykinin B2 receptor signaling via AT1-B2 receptor heterodimers.

Wilson PC, Lee MH, Appleton KM, El-Shewy HM, Morinelli TA, Peterson YK, Luttrell LM, Jaffa AA. Wilson PC, et al. Among authors: appleton km. J Biol Chem. 2013 Jun 28;288(26):18872-84. doi: 10.1074/jbc.M113.472381. Epub 2013 May 9. J Biol Chem. 2013. PMID: 23661707 Free PMC article.

10

The conformational signature of β-arrestin2 predicts its trafficking and signalling functions.

Lee MH, Appleton KM, Strungs EG, Kwon JY, Morinelli TA, Peterson YK, Laporte SA, Luttrell LM. Lee MH, et al. Among authors: appleton km. Nature. 2016 Mar 31;531(7596):665-8. doi: 10.1038/nature17154. Epub 2016 Mar 23. Nature. 2016. PMID: 27007854 Free PMC article.

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