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Clarithromycin, Midazolam, and Digoxin: Application of PBPK Modeling to Gain New Insights into Drug-Drug Interactions and Co-medication Regimens.
AAPS J. 2017 Jan;19(1):298-312. doi: 10.1208/s12248-016-0009-9. Epub 2016 Nov 7.
AAPS J. 2017.
PMID: 27822600
A physiologically based pharmacokinetic (PBPK) parent-metabolite model of the chemotherapeutic zoptarelin doxorubicin-integration of in vitro results, Phase I and Phase II data and model application for drug-drug interaction potential analysis.
Hanke N, Teifel M, Moj D, Wojtyniak JG, Britz H, Aicher B, Sindermann H, Ammer N, Lehr T.
Hanke N, et al. Among authors: moj d.
Cancer Chemother Pharmacol. 2018 Feb;81(2):291-304. doi: 10.1007/s00280-017-3495-2. Epub 2017 Dec 4.
Cancer Chemother Pharmacol. 2018.
PMID: 29204687
Clinical Trial.
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PBPK Models for CYP3A4 and P-gp DDI Prediction: A Modeling Network of Rifampicin, Itraconazole, Clarithromycin, Midazolam, Alfentanil, and Digoxin.
Hanke N, Frechen S, Moj D, Britz H, Eissing T, Wendl T, Lehr T.
Hanke N, et al. Among authors: moj d.
CPT Pharmacometrics Syst Pharmacol. 2018 Oct;7(10):647-659. doi: 10.1002/psp4.12343. Epub 2018 Sep 7.
CPT Pharmacometrics Syst Pharmacol. 2018.
PMID: 30091221
Free PMC article.
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A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model of the histone deacetylase (HDAC) inhibitor vorinostat for pediatric and adult patients and its application for dose specification.
Moj D, Britz H, Burhenne J, Stewart CF, Egerer G, Haefeli WE, Lehr T.
Moj D, et al.
Cancer Chemother Pharmacol. 2017 Nov;80(5):1013-1026. doi: 10.1007/s00280-017-3447-x. Epub 2017 Oct 7.
Cancer Chemother Pharmacol. 2017.
PMID: 28988277
Free PMC article.
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A Comprehensive Whole-Body Physiologically Based Pharmacokinetic Model of Dabigatran Etexilate, Dabigatran and Dabigatran Glucuronide in Healthy Adults and Renally Impaired Patients.
Moj D, Maas H, Schaeftlein A, Hanke N, Gómez-Mantilla JD, Lehr T.
Moj D, et al.
Clin Pharmacokinet. 2019 Dec;58(12):1577-1593. doi: 10.1007/s40262-019-00776-y.
Clin Pharmacokinet. 2019.
PMID: 31104266
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A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug-Drug Interactions.
Li X, Frechen S, Moj D, Lehr T, Taubert M, Hsin CH, Mikus G, Neuvonen PJ, Olkkola KT, Saari TI, Fuhr U.
Li X, et al. Among authors: moj d.
Clin Pharmacokinet. 2020 Jun;59(6):781-808. doi: 10.1007/s40262-019-00856-z.
Clin Pharmacokinet. 2020.
PMID: 31853755
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The feasibility of physiologically based pharmacokinetic modeling in forensic medicine illustrated by the example of morphine.
Schaefer N, Moj D, Lehr T, Schmidt PH, Ramsthaler F.
Schaefer N, et al. Among authors: moj d.
Int J Legal Med. 2018 Mar;132(2):415-424. doi: 10.1007/s00414-017-1754-8. Epub 2017 Dec 1.
Int J Legal Med. 2018.
PMID: 29196879
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