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CYP3A4-mediated effects of rifampicin on the pharmacokinetics of vilaprisan and its UGT1A1-mediated effects on bilirubin glucuronidation in humans.
Chattopadhyay N, Kanacher T, Casjens M, Frechen S, Ligges S, Zimmermann T, Rottmann A, Ploeger B, Höchel J, Schultze-Mosgau MH. Chattopadhyay N, et al. Among authors: frechen s. Br J Clin Pharmacol. 2018 Dec;84(12):2857-2866. doi: 10.1111/bcp.13750. Epub 2018 Oct 11. Br J Clin Pharmacol. 2018. PMID: 30171692 Free PMC article.
Physiologically-Based Pharmacokinetic Models for CYP1A2 Drug-Drug Interaction Prediction: A Modeling Network of Fluvoxamine, Theophylline, Caffeine, Rifampicin, and Midazolam.
Britz H, Hanke N, Volz AK, Spigset O, Schwab M, Eissing T, Wendl T, Frechen S, Lehr T. Britz H, et al. Among authors: frechen s. CPT Pharmacometrics Syst Pharmacol. 2019 May;8(5):296-307. doi: 10.1002/psp4.12397. Epub 2019 Mar 13. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 30762305 Free PMC article.
Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug-Drug-Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole.
Türk D, Hanke N, Wolf S, Frechen S, Eissing T, Wendl T, Schwab M, Lehr T. Türk D, et al. Among authors: frechen s. Clin Pharmacokinet. 2019 Dec;58(12):1595-1607. doi: 10.1007/s40262-019-00777-x. Clin Pharmacokinet. 2019. PMID: 31129789 Free PMC article.
Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences.
Lippert J, Burghaus R, Edginton A, Frechen S, Karlsson M, Kovar A, Lehr T, Milligan P, Nock V, Ramusovic S, Riggs M, Schaller S, Schlender J, Schmidt S, Sevestre M, Sjögren E, Solodenko J, Staab A, Teutonico D. Lippert J, et al. Among authors: frechen s. CPT Pharmacometrics Syst Pharmacol. 2019 Dec;8(12):878-882. doi: 10.1002/psp4.12473. Epub 2019 Nov 12. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31671256 Free PMC article. Review. No abstract available.
A generic framework for the physiologically-based pharmacokinetic platform qualification of PK-Sim and its application to predicting cytochrome P450 3A4-mediated drug-drug interactions.
Frechen S, Solodenko J, Wendl T, Dallmann A, Ince I, Lehr T, Lippert J, Burghaus R. Frechen S, et al. CPT Pharmacometrics Syst Pharmacol. 2021 Jun;10(6):633-644. doi: 10.1002/psp4.12636. Epub 2021 May 24. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 33946131 Free PMC article.
Predictive Performance of Physiology-Based Pharmacokinetic Dose Estimates for Pediatric Trials: Evaluation With 10 Bayer Small-Molecule Compounds in Children.
Ince I, Dallmann A, Frechen S, Coboeken K, Niederalt C, Wendl T, Block M, Meyer M, Eissing T, Burghaus R, Lippert J, Willmann S, Schlender JF. Ince I, et al. Among authors: frechen s. J Clin Pharmacol. 2021 Jun;61 Suppl 1(Suppl 1):S70-S82. doi: 10.1002/jcph.1869. J Clin Pharmacol. 2021. PMID: 34185905 Free PMC article.
39 results