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Imprime PGG-Mediated Anti-Cancer Immune Activation Requires Immune Complex Formation.
Chan AS, Jonas AB, Qiu X, Ottoson NR, Walsh RM, Gorden KB, Harrison B, Maimonis PJ, Leonardo SM, Ertelt KE, Danielson ME, Michel KS, Nelson M, Graff JR, Patchen ML, Bose N. Chan AS, et al. Among authors: patchen ml. PLoS One. 2016 Nov 3;11(11):e0165909. doi: 10.1371/journal.pone.0165909. eCollection 2016. PLoS One. 2016. PMID: 27812183 Free PMC article.
A randomized, open-label, multicenter, phase II study evaluating the efficacy and safety of BTH1677 (1,3-1,6 beta glucan; Imprime PGG) in combination with cetuximab and chemotherapy in patients with advanced non-small cell lung cancer.
Thomas M, Sadjadian P, Kollmeier J, Lowe J, Mattson P, Trout JR, Gargano M, Patchen ML, Walsh R, Beliveau M, Marier JF, Bose N, Gorden K, Schneller F 3rd. Thomas M, et al. Among authors: patchen ml. Invest New Drugs. 2017 Jun;35(3):345-358. doi: 10.1007/s10637-017-0450-3. Epub 2017 Mar 16. Invest New Drugs. 2017. PMID: 28303530 Free PMC article. Clinical Trial.
Binding of Soluble Yeast β-Glucan to Human Neutrophils and Monocytes is Complement-Dependent.
Bose N, Chan AS, Guerrero F, Maristany CM, Qiu X, Walsh RM, Ertelt KE, Jonas AB, Gorden KB, Dudney CM, Wurst LR, Danielson ME, Elmasry N, Magee AS, Patchen ML, Vasilakos JP. Bose N, et al. Among authors: patchen ml. Front Immunol. 2013 Aug 12;4:230. doi: 10.3389/fimmu.2013.00230. eCollection 2013. Front Immunol. 2013. PMID: 23964276 Free PMC article.
Two randomized, double-blind, placebo-controlled, dose-escalation phase 1 studies evaluating BTH1677, a 1, 3-1,6 beta glucan pathogen associated molecular pattern, in healthy volunteer subjects.
Halstenson CE, Shamp T, Gargano MA, Walsh RM, Patchen ML. Halstenson CE, et al. Among authors: patchen ml. Invest New Drugs. 2016 Apr;34(2):202-15. doi: 10.1007/s10637-016-0325-z. Epub 2016 Feb 11. Invest New Drugs. 2016. PMID: 26865390 Free PMC article. Clinical Trial.
A randomized, controlled trial evaluating the efficacy and safety of BTH1677 in combination with bevacizumab, carboplatin, and paclitaxel in first-line treatment of advanced non-small cell lung cancer.
Engel-Riedel W, Lowe J, Mattson P, Richard Trout J, Huhn RD, Gargano M, Patchen ML, Walsh R, Trinh MM, Dupuis M, Schneller F. Engel-Riedel W, et al. Among authors: patchen ml. J Immunother Cancer. 2018 Feb 27;6(1):16. doi: 10.1186/s40425-018-0324-z. J Immunother Cancer. 2018. PMID: 29486797 Free PMC article. Clinical Trial.
72 results