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Loss of 5α-reductase type 1 accelerates the development of hepatic steatosis but protects against hepatocellular carcinoma in male mice.
Dowman JK, Hopkins LJ, Reynolds GM, Armstrong MJ, Nasiri M, Nikolaou N, van Houten EL, Visser JA, Morgan SA, Lavery GG, Oprescu A, Hübscher SG, Newsome PN, Tomlinson JW. Dowman JK, et al. Among authors: tomlinson jw. Endocrinology. 2013 Dec;154(12):4536-47. doi: 10.1210/en.2013-1592. Epub 2013 Sep 30. Endocrinology. 2013. PMID: 24080367 Free PMC article.
Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat/fructose diet and sedentary lifestyle.
Dowman JK, Hopkins LJ, Reynolds GM, Nikolaou N, Armstrong MJ, Shaw JC, Houlihan DD, Lalor PF, Tomlinson JW, Hübscher SG, Newsome PN. Dowman JK, et al. Among authors: tomlinson jw. Am J Pathol. 2014 May;184(5):1550-61. doi: 10.1016/j.ajpath.2014.01.034. Epub 2014 Mar 17. Am J Pathol. 2014. PMID: 24650559 Free PMC article.
Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man.
Hazlehurst JM, Oprescu AI, Nikolaou N, Di Guida R, Grinbergs AE, Davies NP, Flintham RB, Armstrong MJ, Taylor AE, Hughes BA, Yu J, Hodson L, Dunn WB, Tomlinson JW. Hazlehurst JM, et al. Among authors: tomlinson jw. J Clin Endocrinol Metab. 2016 Jan;101(1):103-13. doi: 10.1210/jc.2015-2928. Epub 2015 Nov 17. J Clin Endocrinol Metab. 2016. PMID: 26574953 Free PMC article. Clinical Trial.
AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells.
Nikolaou N, Gathercole LL, Kirkwood L, Dunford JE, Hughes BA, Gilligan LC, Oppermann U, Penning TM, Arlt W, Hodson L, Tomlinson JW. Nikolaou N, et al. Among authors: tomlinson jw. J Steroid Biochem Mol Biol. 2019 May;189:218-227. doi: 10.1016/j.jsbmb.2019.02.002. Epub 2019 Feb 12. J Steroid Biochem Mol Biol. 2019. PMID: 30769091 Free PMC article.
AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease.
Nikolaou N, Gathercole LL, Marchand L, Althari S, Dempster NJ, Green CJ, van de Bunt M, McNeil C, Arvaniti A, Hughes BA, Sgromo B, Gillies RS, Marschall HU, Penning TM, Ryan J, Arlt W, Hodson L, Tomlinson JW. Nikolaou N, et al. Among authors: tomlinson jw. Metabolism. 2019 Oct;99:67-80. doi: 10.1016/j.metabol.2019.153947. Epub 2019 Jul 19. Metabolism. 2019. PMID: 31330134 Free PMC article.
206 results