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Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3.
Prickaerts P, Adriaens ME, Beucken TVD, Koch E, Dubois L, Dahlmans VEH, Gits C, Evelo CTA, Chan-Seng-Yue M, Wouters BG, Voncken JW. Prickaerts P, et al. Among authors: koch e. Epigenetics Chromatin. 2016 Oct 26;9:46. doi: 10.1186/s13072-016-0086-0. eCollection 2016. Epigenetics Chromatin. 2016. PMID: 27800026 Free PMC article.
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.
van den Beucken T, Koch E, Chu K, Rupaimoole R, Prickaerts P, Adriaens M, Voncken JW, Harris AL, Buffa FM, Haider S, Starmans MHW, Yao CQ, Ivan M, Ivan C, Pecot CV, Boutros PC, Sood AK, Koritzinsky M, Wouters BG. van den Beucken T, et al. Among authors: koch e. Nat Commun. 2014 Oct 29;5:5203. doi: 10.1038/ncomms6203. Nat Commun. 2014. PMID: 25351418 Free PMC article.
Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression.
Rupaimoole R, Wu SY, Pradeep S, Ivan C, Pecot CV, Gharpure KM, Nagaraja AS, Armaiz-Pena GN, McGuire M, Zand B, Dalton HJ, Filant J, Miller JB, Lu C, Sadaoui NC, Mangala LS, Taylor M, van den Beucken T, Koch E, Rodriguez-Aguayo C, Huang L, Bar-Eli M, Wouters BG, Radovich M, Ivan M, Calin GA, Zhang W, Lopez-Berestein G, Sood AK. Rupaimoole R, et al. Among authors: koch e. Nat Commun. 2014 Oct 29;5:5202. doi: 10.1038/ncomms6202. Nat Commun. 2014. PMID: 25351346 Free PMC article.
Author Correction: Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression.
Rupaimoole R, Wu SY, Pradeep S, Ivan C, Pecot CV, Gharpure KM, Nagaraja AS, Armaiz-Pena GN, McGuire M, Zand B, Dalton HJ, Filant J, Miller JB, Lu C, Sadaoui NC, Mangala LS, Taylor M, van den Beucken T, Koch E, Rodriguez-Aguayo C, Huang L, Bar-Eli M, Wouters BG, Radovich M, Ivan M, Calin GA, Zhang W, Lopez-Berestein G, Sood AK. Rupaimoole R, et al. Among authors: koch e. Nat Commun. 2020 Jun 3;11(1):2867. doi: 10.1038/s41467-020-16661-3. Nat Commun. 2020. PMID: 32493919 Free PMC article.
A global genetic interaction network maps a wiring diagram of cellular function.
Costanzo M, VanderSluis B, Koch EN, Baryshnikova A, Pons C, Tan G, Wang W, Usaj M, Hanchard J, Lee SD, Pelechano V, Styles EB, Billmann M, van Leeuwen J, van Dyk N, Lin ZY, Kuzmin E, Nelson J, Piotrowski JS, Srikumar T, Bahr S, Chen Y, Deshpande R, Kurat CF, Li SC, Li Z, Usaj MM, Okada H, Pascoe N, San Luis BJ, Sharifpoor S, Shuteriqi E, Simpkins SW, Snider J, Suresh HG, Tan Y, Zhu H, Malod-Dognin N, Janjic V, Przulj N, Troyanskaya OG, Stagljar I, Xia T, Ohya Y, Gingras AC, Raught B, Boutros M, Steinmetz LM, Moore CL, Rosebrock AP, Caudy AA, Myers CL, Andrews B, Boone C. Costanzo M, et al. Among authors: koch en. Science. 2016 Sep 23;353(6306):aaf1420. doi: 10.1126/science.aaf1420. Science. 2016. PMID: 27708008 Free PMC article.
Systematic analysis of complex genetic interactions.
Kuzmin E, VanderSluis B, Wang W, Tan G, Deshpande R, Chen Y, Usaj M, Balint A, Mattiazzi Usaj M, van Leeuwen J, Koch EN, Pons C, Dagilis AJ, Pryszlak M, Wang JZY, Hanchard J, Riggi M, Xu K, Heydari H, San Luis BJ, Shuteriqi E, Zhu H, Van Dyk N, Sharifpoor S, Costanzo M, Loewith R, Caudy A, Bolnick D, Brown GW, Andrews BJ, Boone C, Myers CL. Kuzmin E, et al. Among authors: koch en. Science. 2018 Apr 20;360(6386):eaao1729. doi: 10.1126/science.aao1729. Science. 2018. PMID: 29674565 Free PMC article.
Exploring whole-genome duplicate gene retention with complex genetic interaction analysis.
Kuzmin E, VanderSluis B, Nguyen Ba AN, Wang W, Koch EN, Usaj M, Khmelinskii A, Usaj MM, van Leeuwen J, Kraus O, Tresenrider A, Pryszlak M, Hu MC, Varriano B, Costanzo M, Knop M, Moses A, Myers CL, Andrews BJ, Boone C. Kuzmin E, et al. Among authors: koch en. Science. 2020 Jun 26;368(6498):eaaz5667. doi: 10.1126/science.aaz5667. Science. 2020. PMID: 32586993 Free PMC article.
Environmental robustness of the global yeast genetic interaction network.
Costanzo M, Hou J, Messier V, Nelson J, Rahman M, VanderSluis B, Wang W, Pons C, Ross C, Ušaj M, San Luis BJ, Shuteriqi E, Koch EN, Aloy P, Myers CL, Boone C, Andrews B. Costanzo M, et al. Among authors: koch en. Science. 2021 May 7;372(6542):eabf8424. doi: 10.1126/science.abf8424. Science. 2021. PMID: 33958448 Free PMC article.
Exploring Quantitative Yeast Phenomics with Single-Cell Analysis of DNA Damage Foci.
Styles EB, Founk KJ, Zamparo LA, Sing TL, Altintas D, Ribeyre C, Ribaud V, Rougemont J, Mayhew D, Costanzo M, Usaj M, Verster AJ, Koch EN, Novarina D, Graf M, Luke B, Muzi-Falconi M, Myers CL, Mitra RD, Shore D, Brown GW, Zhang Z, Boone C, Andrews BJ. Styles EB, et al. Cell Syst. 2016 Sep 28;3(3):264-277.e10. doi: 10.1016/j.cels.2016.08.008. Epub 2016 Sep 8. Cell Syst. 2016. PMID: 27617677 Free PMC article.
891 results