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Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses.
Nat Med. 2016 Dec;22(12):1402-1410. doi: 10.1038/nm.4200. Epub 2016 Oct 24.
Nat Med. 2016.
PMID: 27775706
Free PMC article.
What, Why, Where, and When: Bringing Timing to Immuno-Oncology.
Rothschilds AM, Wittrup KD.
Rothschilds AM, et al.
Trends Immunol. 2019 Jan;40(1):12-21. doi: 10.1016/j.it.2018.11.003. Epub 2018 Dec 10.
Trends Immunol. 2019.
PMID: 30545676
Review.
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Pharmacokinetic tuning of protein-antigen fusions enhances the immunogenicity of T-cell vaccines.
Mehta NK, Pradhan RV, Soleimany AP, Moynihan KD, Rothschilds AM, Momin N, Rakhra K, Mata-Fink J, Bhatia SN, Wittrup KD, Irvine DJ.
Mehta NK, et al. Among authors: rothschilds am.
Nat Biomed Eng. 2020 Jun;4(6):636-648. doi: 10.1038/s41551-020-0563-4. Epub 2020 Jun 1.
Nat Biomed Eng. 2020.
PMID: 32483299
Free PMC article.
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Order of administration of combination cytokine therapies can decouple toxicity from efficacy in syngeneic mouse tumor models.
Rothschilds A, Tzeng A, Mehta NK, Moynihan KD, Irvine DJ, Wittrup KD.
Rothschilds A, et al.
Oncoimmunology. 2019 Feb 19;8(5):e1558678. doi: 10.1080/2162402X.2018.1558678. eCollection 2019.
Oncoimmunology. 2019.
PMID: 31069130
Free PMC article.
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Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies.
Lutz EA, Agarwal Y, Momin N, Cowles SC, Palmeri JR, Duong E, Hornet V, Sheen A, Lax BM, Rothschilds AM, Irvine DJ, Spranger S, Wittrup KD.
Lutz EA, et al. Among authors: rothschilds am.
Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2205983119. doi: 10.1073/pnas.2205983119. Epub 2022 Aug 29.
Proc Natl Acad Sci U S A. 2022.
PMID: 36037341
Free PMC article.
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Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti-CTLA-4 antibodies.
Lax BM, Palmeri JR, Lutz EA, Sheen A, Stinson JA, Duhamel L, Santollani L, Kennedy A, Rothschilds AM, Spranger S, Sansom DM, Wittrup KD.
Lax BM, et al. Among authors: rothschilds am.
Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2300895120. doi: 10.1073/pnas.2300895120. Epub 2023 Jul 24.
Proc Natl Acad Sci U S A. 2023.
PMID: 37487077
Free PMC article.
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