Giordanetto F - Search Results

1

Discovery of AZD2716: A Novel Secreted Phospholipase A₂ (sPLA₂) Inhibitor for the Treatment of Coronary Artery Disease.

Giordanetto F, Pettersen D, Starke I, Nordberg P, Dahlström M, Knerr L, Selmi N, Rosengren B, Larsson LO, Sandmark J, Castaldo M, Dekker N, Karlsson U, Hurt-Camejo E. Giordanetto F, et al. ACS Med Chem Lett. 2016 Aug 9;7(10):884-889. doi: 10.1021/acsmedchemlett.6b00188. eCollection 2016 Oct 13. ACS Med Chem Lett. 2016. PMID: 27774123 Free PMC article.

2

Discovery of cyclopentane- and cyclohexane-trans-1,3-diamines as potent melanin-concentrating hormone receptor 1 antagonists.

Giordanetto F, Karlsson O, Lindberg J, Larsson LO, Linusson A, Evertsson E, Morgan DG, Inghardt T. Giordanetto F, et al. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4232-41. doi: 10.1016/j.bmcl.2007.05.034. Epub 2007 May 17. Bioorg Med Chem Lett. 2007. PMID: 17532215

3

Discovery of 1,3-disubstituted-1H-pyrrole derivatives as potent melanin-concentrating hormone receptor 1 (MCH-R1) antagonists.

Berglund S, Egner BJ, Gradén H, Gradén J, Morgan DG, Inghardt T, Giordanetto F. Berglund S, et al. Among authors: giordanetto f. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4859-63. doi: 10.1016/j.bmcl.2008.07.079. Epub 2008 Jul 24. Bioorg Med Chem Lett. 2008. PMID: 18682323

4

Optimization of 2-piperidin-4-yl-acetamides as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists: Designing out hERG inhibition.

Berglund S, Egner BJ, Gradén H, Gradén J, Morgan DG, Inghardt T, Giordanetto F. Berglund S, et al. Among authors: giordanetto f. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4268-73. doi: 10.1016/j.bmcl.2009.05.067. Epub 2009 May 24. Bioorg Med Chem Lett. 2009. PMID: 19500979

5

Optimization of piperidin-4-yl-urea-containing melanin-concentrating hormone receptor 1 (MCH-R1) antagonists: Reducing hERG-associated liabilities.

Berglund S, Egner BJ, Gradén H, Gradén J, Morgan DG, Inghardt T, Giordanetto F. Berglund S, et al. Among authors: giordanetto f. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4274-9. doi: 10.1016/j.bmcl.2009.05.066. Epub 2009 May 27. Bioorg Med Chem Lett. 2009. PMID: 19500982

6

T-type calcium channels inhibitors: a patent review.

Giordanetto F, Knerr L, Wållberg A. Giordanetto F, et al. Expert Opin Ther Pat. 2011 Jan;21(1):85-101. doi: 10.1517/13543776.2011.536532. Epub 2010 Nov 19. Expert Opin Ther Pat. 2011. PMID: 21087200 Review.

7

Discovery of N-(1-adamantyl)-2-(4-alkylpiperazin-1-yl)acetamide derivatives as T-type calcium channel (Cav3.2) inhibitors.

Giordanetto F, Knerr L, Selmi N, Llinàs A, Lindqvist A, Wang QD, Ståhlberg P, Thorstensson F, Ullah V, Nilsson K, O'Mahony G, Högberg G, Lindhardt E, Strand A, Duker G. Giordanetto F, et al. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5557-61. doi: 10.1016/j.bmcl.2011.06.092. Epub 2011 Jun 30. Bioorg Med Chem Lett. 2011. PMID: 21782423

8

Discovery of 4-hydroxy-1,6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors.

Bauer U, Giordanetto F, Bauer M, O'Mahony G, Johansson KE, Knecht W, Hartleib-Geschwindner J, Carlsson ET, Enroth C. Bauer U, et al. Among authors: giordanetto f. Bioorg Med Chem Lett. 2012 Mar 1;22(5):1944-8. doi: 10.1016/j.bmcl.2012.01.046. Epub 2012 Jan 26. Bioorg Med Chem Lett. 2012. PMID: 22321214

9

Discovery of phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, an effective antithrombotic agent without associated bleeding and insulin resistance.

Giordanetto F, Wållberg A, Ghosal S, Iliefski T, Cassel J, Yuan ZQ, von Wachenfeldt H, Andersen SM, Inghardt T, Tunek A, Nylander S. Giordanetto F, et al. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6671-6. doi: 10.1016/j.bmcl.2012.08.102. Epub 2012 Sep 6. Bioorg Med Chem Lett. 2012. PMID: 23010262

10

Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing Phosphoinositide 3-kinase (PI3K) p110β isoform inhibitors through structure-based fragment optimisation.

Giordanetto F, Wållberg A, Cassel J, Ghosal S, Kossenjans M, Yuan ZQ, Wang X, Liang L. Giordanetto F, et al. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6665-70. doi: 10.1016/j.bmcl.2012.08.101. Epub 2012 Sep 7. Bioorg Med Chem Lett. 2012. PMID: 23010274

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