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Applicability of predictive toxicology methods for monoclonal antibody therapeutics: status Quo and scope.
Arch Toxicol. 2017 Apr;91(4):1595-1612. doi: 10.1007/s00204-016-1876-7. Epub 2016 Oct 20.
Arch Toxicol. 2017.
PMID: 27766364
Free PMC article.
Review.
Cross-Interaction Chromatography-Based QSAR Model for Early-Stage Screening to Facilitate Enhanced Developability of Monoclonal Antibody Therapeutics.
Kizhedath A, Karlberg M, Glassey J.
Kizhedath A, et al.
Biotechnol J. 2019 Aug;14(8):e1800696. doi: 10.1002/biot.201800696. Epub 2019 Apr 17.
Biotechnol J. 2019.
PMID: 30810283
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Applicability of Traditional In Vitro Toxicity Tests for Assessing Adverse Effects of Monoclonal Antibodies: A Case Study of Rituximab and Trastuzumab.
Kizhedath A, Wilkinson S, Glassey J.
Kizhedath A, et al.
Antibodies (Basel). 2018 Aug 17;7(3):30. doi: 10.3390/antib7030030.
Antibodies (Basel). 2018.
PMID: 31544882
Free PMC article.
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QSAR Implementation for HIC Retention Time Prediction of mAbs Using Fab Structure: A Comparison between Structural Representations.
Karlberg M, de Souza JV, Fan L, Kizhedath A, Bronowska AK, Glassey J.
Karlberg M, et al. Among authors: kizhedath a.
Int J Mol Sci. 2020 Oct 28;21(21):8037. doi: 10.3390/ijms21218037.
Int J Mol Sci. 2020.
PMID: 33126648
Free PMC article.
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Assessment of hepatotoxicity and dermal toxicity of butyl paraben and methyl paraben using HepG2 and HDFn in vitro models.
Kizhedath A, Wilkinson S, Glassey J.
Kizhedath A, et al.
Toxicol In Vitro. 2019 Mar;55:108-115. doi: 10.1016/j.tiv.2018.12.007. Epub 2018 Dec 17.
Toxicol In Vitro. 2019.
PMID: 30572011
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A Human Skin Explant Test as a Novel In Vitro Assay for the Detection of Skin Sensitization to Aggregated Monoclonal Antibodies.
Martins-Ribeiro A, Kizhedath A, Ahmed SS, Glassey J, Ishaq A, Freer M, Dickinson AM.
Martins-Ribeiro A, et al. Among authors: kizhedath a.
Toxics. 2024 Apr 30;12(5):332. doi: 10.3390/toxics12050332.
Toxics. 2024.
PMID: 38787111
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