Wünsch B - Search Results

1

Combinatorial effects of doxorubicin and retargeted tissue factor by intratumoral entrapment of doxorubicin and proapoptotic increase of tumor vascular infarction.

Stucke-Ring J, Ronnacker J, Brand C, Höltke C, Schliemann C, Kessler T, Schmidt LH, Harrach S, Mantke V, Hintelmann H, Hartmann W, Wardelmann E, Lenz G, Wünsch B, Müller-Tidow C, Mesters RM, Schwöppe C, Berdel WE. Stucke-Ring J, et al. Among authors: wunsch b. Oncotarget. 2016 Dec 13;7(50):82458-82472. doi: 10.18632/oncotarget.12559. Oncotarget. 2016. PMID: 27738341 Free PMC article.

2

Characterization of ligand binding to the σ(1) receptor in a human tumor cell line (RPMI 8226) and establishment of a competitive receptor binding assay.

Brune S, Schepmann D, Lehmkuhl K, Frehland B, Wünsch B. Brune S, et al. Among authors: wunsch b. Assay Drug Dev Technol. 2012 Aug;10(4):365-74. doi: 10.1089/adt.2011.0376. Epub 2011 Dec 22. Assay Drug Dev Technol. 2012. PMID: 22192304

3

Involvement of apoptosis and autophagy in the death of RPMI 8226 multiple myeloma cells by two enantiomeric sigma receptor ligands.

Korpis K, Weber F, Brune S, Wünsch B, Bednarski PJ. Korpis K, et al. Among authors: wunsch b. Bioorg Med Chem. 2014 Jan 1;22(1):221-33. doi: 10.1016/j.bmc.2013.11.033. Epub 2013 Nov 25. Bioorg Med Chem. 2014. PMID: 24331758

4

Synthesis and biological evaluation of new aryl-alkyl(alkenyl)-4-benzylpiperidines, novel Sigma Receptor (SR) modulators, as potential anticancer-agents.

Rui M, Rossi D, Marra A, Paolillo M, Schinelli S, Curti D, Tesei A, Cortesi M, Zamagni A, Laurini E, Pricl S, Schepmann D, Wűnsch B, Urban E, Pace V, Collina S. Rui M, et al. Among authors: wunsch b. Eur J Med Chem. 2016 Nov 29;124:649-665. doi: 10.1016/j.ejmech.2016.08.067. Epub 2016 Aug 31. Eur J Med Chem. 2016. PMID: 27614411

5

Medicinal Chemistry of σ₁ Receptor Ligands: Pharmacophore Models, Synthesis, Structure Affinity Relationships, and Pharmacological Applications.

Weber F, Wünsch B. Weber F, et al. Among authors: wunsch b. Handb Exp Pharmacol. 2017;244:51-79. doi: 10.1007/164_2017_33. Handb Exp Pharmacol. 2017. PMID: 28620761 Review.

6

Synthesis, pharmacological evaluation, and σ1 receptor interaction analysis of hydroxyethyl substituted piperazines.

Weber F, Brune S, Korpis K, Bednarski PJ, Laurini E, Dal Col V, Pricl S, Schepmann D, Wünsch B. Weber F, et al. Among authors: wunsch b. J Med Chem. 2014 Apr 10;57(7):2884-94. doi: 10.1021/jm401707t. Epub 2014 Mar 27. J Med Chem. 2014. PMID: 24617836

7

Expression of σ receptors of human urinary bladder tumor cells (RT-4 cells) and development of a competitive receptor binding assay for the determination of ligand affinity to human σ(2) receptors.

Schepmann D, Lehmkuhl K, Brune S, Wünsch B. Schepmann D, et al. Among authors: wunsch b. J Pharm Biomed Anal. 2011 Jul 15;55(5):1136-41. doi: 10.1016/j.jpba.2011.03.044. Epub 2011 Apr 8. J Pharm Biomed Anal. 2011. PMID: 21550749

8

Structure of the σ1 receptor and its ligand binding site.

Brune S, Pricl S, Wünsch B. Brune S, et al. Among authors: wunsch b. J Med Chem. 2013 Dec 27;56(24):9809-19. doi: 10.1021/jm400660u. Epub 2013 Sep 10. J Med Chem. 2013. PMID: 23964901 Review.

9

Synthesis of bicyclic sigma receptor ligands with cytotoxic activity.

Geiger C, Zelenka C, Weigl M, Fröhlich R, Wibbeling B, Lehmkuhl K, Schepmann D, Grünert R, Bednarski PJ, Wünsch B. Geiger C, et al. Among authors: wunsch b. J Med Chem. 2007 Nov 29;50(24):6144-53. doi: 10.1021/jm070620b. Epub 2007 Oct 30. J Med Chem. 2007. PMID: 17967001

10

Synthesis and structure-affinity relationships of novel spirocyclic sigma receptor ligands with furopyrazole structure.

Schläger T, Schepmann D, Würthwein EU, Wünsch B. Schläger T, et al. Among authors: wunsch b. Bioorg Med Chem. 2008 Mar 15;16(6):2992-3001. doi: 10.1016/j.bmc.2007.12.045. Epub 2007 Dec 25. Bioorg Med Chem. 2008. PMID: 18221879

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