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Ran GTPase promotes cancer progression via Met recepto-rmediated downstream signaling.
Yuen HF, Chan KK, Platt-Higgins A, Dakir el-H, Matchett KB, Haggag YA, Jithesh PV, Habib T, Faheem A, Dean FA, Morgan R, Rudland PS, El-Tanani M. Yuen HF, et al. Among authors: rudland ps. Oncotarget. 2016 Nov 15;7(46):75854-75864. doi: 10.18632/oncotarget.12420. Oncotarget. 2016. PMID: 27716616 Free PMC article.
Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways.
Yuen HF, Chan KK, Grills C, Murray JT, Platt-Higgins A, Eldin OS, O'Byrne K, Janne P, Fennell DA, Johnston PG, Rudland PS, El-Tanani M. Yuen HF, et al. Among authors: rudland ps. Clin Cancer Res. 2012 Jan 15;18(2):380-91. doi: 10.1158/1078-0432.CCR-11-2035. Epub 2011 Nov 16. Clin Cancer Res. 2012. PMID: 22090358 Free PMC article.
RanGTPase: a candidate for Myc-mediated cancer progression.
Yuen HF, Gunasekharan VK, Chan KK, Zhang SD, Platt-Higgins A, Gately K, O'Byrne K, Fennell DA, Johnston PG, Rudland PS, El-Tanani M. Yuen HF, et al. Among authors: rudland ps. J Natl Cancer Inst. 2013 Apr 3;105(7):475-88. doi: 10.1093/jnci/djt028. Epub 2013 Mar 6. J Natl Cancer Inst. 2013. PMID: 23468463 Free article.
Erythropoietin drives breast cancer progression by activation of its receptor EPOR.
Chan KK, Matchett KB, Coulter JA, Yuen HF, McCrudden CM, Zhang SD, Irwin GW, Davidson MA, Rülicke T, Schober S, Hengst L, Jaekel H, Platt-Higgins A, Rudland PS, Mills KI, Maxwell P, El-Tanani M, Lappin TR. Chan KK, et al. Among authors: rudland ps. Oncotarget. 2017 Jun 13;8(24):38251-38263. doi: 10.18632/oncotarget.16368. Oncotarget. 2017. PMID: 28418910 Free PMC article.
The anti-psychotic drug pimozide is a novel chemotherapeutic for breast cancer.
Dakir el-H, Pickard A, Srivastava K, McCrudden CM, Gross SR, Lloyd S, Zhang SD, Margariti A, Morgan R, Rudland PS, El-Tanani M. Dakir el-H, et al. Among authors: rudland ps. Oncotarget. 2018 Oct 9;9(79):34889-34910. doi: 10.18632/oncotarget.26175. eCollection 2018 Oct 9. Oncotarget. 2018. PMID: 30405882 Free PMC article.
Protein deregulation associated with breast cancer metastasis.
Chan KK, Matchett KB, McEnhill PM, Dakir el H, McMullin MF, El-Tanani Y, Patterson L, Faheem A, Rudland PS, McCarron PA, El-Tanani M. Chan KK, et al. Among authors: rudland ps. Cytokine Growth Factor Rev. 2015 Aug;26(4):415-23. doi: 10.1016/j.cytogfr.2015.05.002. Epub 2015 May 31. Cytokine Growth Factor Rev. 2015. PMID: 26088937 Review.
276 results