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Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome.
Pharmaceuticals (Basel). 2010 Jun 4;3(6):1842-1872. doi: 10.3390/ph3061842.
Pharmaceuticals (Basel). 2010.
PMID: 27713332
Free PMC article.
Review.
Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38alpha(MAPK) inhibitors in Werner syndrome cells.
Davis T, Bagley MC, Dix MC, Murziani PG, Rokicki MJ, Widdowson CS, Zayed JM, Bachler MA, Kipling D.
Davis T, et al. Among authors: murziani pg.
Bioorg Med Chem Lett. 2007 Dec 15;17(24):6832-5. doi: 10.1016/j.bmcl.2007.10.036. Epub 2007 Oct 17.
Bioorg Med Chem Lett. 2007.
PMID: 17964780
Item in Clipboard
Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38(MAPK) inhibitor RO3201195 for study in Werner syndrome cells.
Bagley MC, Davis T, Dix MC, Murziani PG, Rokicki MJ, Kipling D.
Bagley MC, et al. Among authors: murziani pg.
Bioorg Med Chem Lett. 2008 Jul 1;18(13):3745-8. doi: 10.1016/j.bmcl.2008.05.037. Epub 2008 May 16.
Bioorg Med Chem Lett. 2008.
PMID: 18539026
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Microwave-assisted synthesis of a pyrazolyl ketone library for evaluation as p38 MAPK inhibitors in Werner syndrome cells.
Bagley MC, Davis T, Dix MC, Murziani PG, Rokicki MJ, Kipling D.
Bagley MC, et al. Among authors: murziani pg.
Future Med Chem. 2010 Feb;2(2):203-13. doi: 10.4155/fmc.09.160.
Future Med Chem. 2010.
PMID: 21426187
Item in Clipboard
The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells.
Bagley MC, Dwyer JE, Baashen M, Dix MC, Murziani PG, Rokicki MJ, Kipling D, Davis T.
Bagley MC, et al. Among authors: murziani pg.
Org Biomol Chem. 2016 Jan 21;14(3):947-56. doi: 10.1039/c5ob02229k. Epub 2015 Nov 27.
Org Biomol Chem. 2016.
PMID: 26611938
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Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.
McGuigan C, Murziani P, Slusarczyk M, Gonczy B, Vande Voorde J, Liekens S, Balzarini J.
McGuigan C, et al.
J Med Chem. 2011 Oct 27;54(20):7247-58. doi: 10.1021/jm200815w. Epub 2011 Sep 27.
J Med Chem. 2011.
PMID: 21892829
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The cytostatic activity of NUC-3073, a phosphoramidate prodrug of 5-fluoro-2'-deoxyuridine, is independent of activation by thymidine kinase and insensitive to degradation by phosphorolytic enzymes.
Vande Voorde J, Liekens S, McGuigan C, Murziani PG, Slusarczyk M, Balzarini J.
Vande Voorde J, et al. Among authors: murziani pg.
Biochem Pharmacol. 2011 Sep 1;82(5):441-52. doi: 10.1016/j.bcp.2011.05.024. Epub 2011 May 31.
Biochem Pharmacol. 2011.
PMID: 21658373
Free article.
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