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Discovery and Characterization of Allosteric WNK Kinase Inhibitors.
Yamada K, Zhang JH, Xie X, Reinhardt J, Xie AQ, LaSala D, Kohls D, Yowe D, Burdick D, Yoshisue H, Wakai H, Schmidt I, Gunawan J, Yasoshima K, Yue QK, Kato M, Mogi M, Idamakanti N, Kreder N, Drueckes P, Pandey P, Kawanami T, Huang W, Yagi YI, Deng Z, Park HM. Yamada K, et al. Among authors: schmidt i. ACS Chem Biol. 2016 Dec 16;11(12):3338-3346. doi: 10.1021/acschembio.6b00511. Epub 2016 Oct 19. ACS Chem Biol. 2016. PMID: 27712055
Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy.
Potting C, Crochemore C, Moretti F, Nigsch F, Schmidt I, Manneville C, Carbone W, Knehr J, DeJesus R, Lindeman A, Maher R, Russ C, McAllister G, Reece-Hoyes JS, Hoffman GR, Roma G, Müller M, Sailer AW, Helliwell SB. Potting C, et al. Among authors: schmidt i. Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E180-E189. doi: 10.1073/pnas.1711023115. Epub 2017 Dec 21. Proc Natl Acad Sci U S A. 2018. PMID: 29269392 Free PMC article.
Small molecule induced STING degradation facilitated by the HECT ligase HERC4.
Mutlu M, Schmidt I, Morrison AI, Goretzki B, Freuler F, Begue D, Simic O, Pythoud N, Ahrne E, Kapps S, Roest S, Bonenfant D, Jeanpierre D, Tran TT, Maher R, An S, Rietsch A, Nigsch F, Hofmann A, Reece-Hoyes J, Parker CN, Guerini D. Mutlu M, et al. Among authors: schmidt i. Nat Commun. 2024 May 29;15(1):4584. doi: 10.1038/s41467-024-48922-w. Nat Commun. 2024. PMID: 38811577 Free PMC article.
Convergence of multiple RNA-silencing pathways on GW182/TNRC6.
Welte T, Goulois A, Stadler MB, Hess D, Soneson C, Neagu A, Azzi C, Wisser MJ, Seebacher J, Schmidt I, Estoppey D, Nigsch F, Reece-Hoyes J, Hoepfner D, Großhans H. Welte T, et al. Among authors: schmidt i. Mol Cell. 2023 Jul 20;83(14):2478-2492.e8. doi: 10.1016/j.molcel.2023.06.001. Epub 2023 Jun 26. Mol Cell. 2023. PMID: 37369201 Free article.
Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control.
Gurzeler LA, Link M, Ibig Y, Schmidt I, Galuba O, Schoenbett J, Gasser-Didierlaurant C, Parker CN, Mao X, Bitsch F, Schirle M, Couttet P, Sigoillot F, Ziegelmüller J, Uldry AC, Teodorowicz W, Schmiedeberg N, Mühlemann O, Reinhardt J. Gurzeler LA, et al. Among authors: schmidt i. Cell Rep. 2023 Sep 26;42(9):113056. doi: 10.1016/j.celrep.2023.113056. Epub 2023 Aug 30. Cell Rep. 2023. PMID: 37651229 Free article.
Serum and Urine Metabolites and Kidney Function.
Yeo WJ, Surapaneni AL, Hasson D, Schmidt IM, Sekula P, Köttgen A, Eckardt KU, Rebholz CM, Yu B, Waikar SS, Rhee EP, Schrauben SJ, Feldman HI, Vasan RS, Kimmel PL, Coresh J, Grams ME, Schlosser P. Yeo WJ, et al. Among authors: schmidt im. J Am Soc Nephrol. 2024 Jun 6. doi: 10.1681/ASN.0000000000000403. Online ahead of print. J Am Soc Nephrol. 2024. PMID: 38844075
610 results