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Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression.
Roy B, Friesen WJ, Tomizawa Y, Leszyk JD, Zhuo J, Johnson B, Dakka J, Trotta CR, Xue X, Mutyam V, Keeling KM, Mobley JA, Rowe SM, Bedwell DM, Welch EM, Jacobson A. Roy B, et al. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12508-12513. doi: 10.1073/pnas.1605336113. Epub 2016 Oct 4. Proc Natl Acad Sci U S A. 2016. PMID: 27702906 Free PMC article.
The nucleoside analog clitocine is a potent and efficacious readthrough agent.
Friesen WJ, Trotta CR, Tomizawa Y, Zhuo J, Johnson B, Sierra J, Roy B, Weetall M, Hedrick J, Sheedy J, Takasugi J, Moon YC, Babu S, Baiazitov R, Leszyk JD, Davis TW, Colacino JM, Peltz SW, Welch EM. Friesen WJ, et al. Among authors: roy b. RNA. 2017 Apr;23(4):567-577. doi: 10.1261/rna.060236.116. Epub 2017 Jan 17. RNA. 2017. PMID: 28096517 Free PMC article.
A highly conserved region essential for NMD in the Upf2 N-terminal domain.
Fourati Z, Roy B, Millan C, Coureux PD, Kervestin S, van Tilbeurgh H, He F, Usón I, Jacobson A, Graille M. Fourati Z, et al. Among authors: roy b. J Mol Biol. 2014 Nov 11;426(22):3689-3702. doi: 10.1016/j.jmb.2014.09.015. Epub 2014 Sep 30. J Mol Biol. 2014. PMID: 25277656 Free PMC article.
Pseudouridinylation of mRNA coding sequences alters translation.
Eyler DE, Franco MK, Batool Z, Wu MZ, Dubuke ML, Dobosz-Bartoszek M, Jones JD, Polikanov YS, Roy B, Koutmou KS. Eyler DE, et al. Among authors: roy b. Proc Natl Acad Sci U S A. 2019 Nov 12;116(46):23068-23074. doi: 10.1073/pnas.1821754116. Epub 2019 Oct 31. Proc Natl Acad Sci U S A. 2019. PMID: 31672910 Free PMC article.
1,753 results