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Production, Quality Control, Stability and Pharmacotoxicity of a Malaria Vaccine Comprising Three Highly Similar PfAMA1 Protein Molecules to Overcome Antigenic Variation.
Faber BW, Hellwig S, Houard S, Havelange N, Drossard J, Mertens H, Croon A, Kastilan R, Byrne R, van der Werff N, van der Eijk M, Thomas AW, Kocken CH, Remarque EJ. Faber BW, et al. Among authors: kastilan r. PLoS One. 2016 Oct 3;11(10):e0164053. doi: 10.1371/journal.pone.0164053. eCollection 2016. PLoS One. 2016. PMID: 27695087 Free PMC article.
Optimization of a multi-stage, multi-subunit malaria vaccine candidate for the production in Pichia pastoris by the identification and removal of protease cleavage sites.
Spiegel H, Schinkel H, Kastilan R, Dahm P, Boes A, Scheuermayer M, Chudobová I, Maskus D, Fendel R, Schillberg S, Reimann A, Fischer R. Spiegel H, et al. Among authors: kastilan r. Biotechnol Bioeng. 2015 Apr;112(4):659-67. doi: 10.1002/bit.25481. Epub 2014 Nov 24. Biotechnol Bioeng. 2015. PMID: 25335451
Production of Functional Anti-Ebola Antibodies in Pichia pastoris.
Purcell O, Opdensteinen P, Chen W, Lowenhaupt K, Brown A, Hermann M, Cao J, Tenhaef N, Kallweit E, Kastilan R, Sinskey AJ, Perez-Pinera P, Buyel JF, Lu TK. Purcell O, et al. Among authors: kastilan r. ACS Synth Biol. 2017 Dec 15;6(12):2183-2190. doi: 10.1021/acssynbio.7b00234. Epub 2017 Aug 17. ACS Synth Biol. 2017. PMID: 28786662