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The FXR agonist obeticholic acid prevents gut barrier dysfunction and bacterial translocation in cholestatic rats.
Verbeke L, Farre R, Verbinnen B, Covens K, Vanuytsel T, Verhaegen J, Komuta M, Roskams T, Chatterjee S, Annaert P, Vander Elst I, Windmolders P, Trebicka J, Nevens F, Laleman W. Verbeke L, et al. Among authors: farre r. Am J Pathol. 2015 Feb;185(2):409-19. doi: 10.1016/j.ajpath.2014.10.009. Epub 2015 Jan 12. Am J Pathol. 2015. PMID: 25592258 Free article.
Duodenal acidification induces gastric relaxation and alters epithelial barrier function by a mast cell independent mechanism.
Vanheel H, Vicario M, Beeckmans D, Cocca S, Wauters L, Accarie A, Toth J, Rodewald HR, De Hertogh G, Matteoli G, Boeckxstaens G, Tack J, Farre R, Vanuytsel T. Vanheel H, et al. Among authors: farre r. Sci Rep. 2020 Oct 15;10(1):17448. doi: 10.1038/s41598-020-74491-1. Sci Rep. 2020. PMID: 33060783 Free PMC article. Clinical Trial.
Overexpression of corticotropin-releasing factor in intestinal mucosal eosinophils is associated with clinical severity in Diarrhea-Predominant Irritable Bowel Syndrome.
Salvo-Romero E, Martínez C, Lobo B, Rodiño-Janeiro BK, Pigrau M, Sánchez-Chardi AD, González-Castro AM, Fortea M, Pardo-Camacho C, Nieto A, Expósito E, Guagnozzi D, Rodríguez-Urrutia A, de Torres I, Farré R, Azpiroz F, Alonso-Cotoner C, Santos J, Vicario M. Salvo-Romero E, et al. Among authors: farre r. Sci Rep. 2020 Nov 26;10(1):20706. doi: 10.1038/s41598-020-77176-x. Sci Rep. 2020. PMID: 33244004 Free PMC article.
Activated intestinal macrophages in patients with cirrhosis release NO and IL-6 that may disrupt intestinal barrier function.
Du Plessis J, Vanheel H, Janssen CE, Roos L, Slavik T, Stivaktas PI, Nieuwoudt M, van Wyk SG, Vieira W, Pretorius E, Beukes M, Farré R, Tack J, Laleman W, Fevery J, Nevens F, Roskams T, Van der Merwe SW. Du Plessis J, et al. Among authors: farre r. J Hepatol. 2013 Jun;58(6):1125-32. doi: 10.1016/j.jhep.2013.01.038. Epub 2013 Feb 9. J Hepatol. 2013. PMID: 23402745
Butyrate Does Not Protect Against Inflammation-induced Loss of Epithelial Barrier Function and Cytokine Production in Primary Cell Monolayers From Patients With Ulcerative Colitis.
Vancamelbeke M, Laeremans T, Vanhove W, Arnauts K, Ramalho AS, Farré R, Cleynen I, Ferrante M, Vermeire S. Vancamelbeke M, et al. Among authors: farre r. J Crohns Colitis. 2019 Sep 27;13(10):1351-1361. doi: 10.1093/ecco-jcc/jjz064. J Crohns Colitis. 2019. PMID: 30919886 Free PMC article.
535 results