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Gepotidacin is efficacious in a nonhuman primate model of pneumonic plague.
Jakielaszek C, Hossain M, Qian L, Fishman C, Widdowson K, Hilliard JJ, Mannino F, Raychaudhuri A, Carniel E, Demons S, Heine HS, Hershfield J, Russo R, Mega WM, Revelli D, O'Dwyer K. Jakielaszek C, et al. Among authors: mega wm. Sci Transl Med. 2022 Jun;14(647):eabg1787. doi: 10.1126/scitranslmed.abg1787. Epub 2022 Jun 1. Sci Transl Med. 2022. PMID: 35648812
Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes.
Langley RJ, Tipper JL, Bruse S, Baron RM, Tsalik EL, Huntley J, Rogers AJ, Jaramillo RJ, O'Donnell D, Mega WM, Keaton M, Kensicki E, Gazourian L, Fredenburgh LE, Massaro AF, Otero RM, Fowler VG Jr, Rivers EP, Woods CW, Kingsmore SF, Sopori ML, Perrella MA, Choi AM, Harrod KS. Langley RJ, et al. Among authors: mega wm. Am J Respir Crit Care Med. 2014 Aug 15;190(4):445-55. doi: 10.1164/rccm.201404-0624OC. Am J Respir Crit Care Med. 2014. PMID: 25054455 Free PMC article.