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Page 1
The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists.
Rech JC, Bhattacharya A, Branstetter BJ, Love CJ, Leenaerts JE, Cooymans LP, Eckert WA 3rd, Ao H, Wang Q, Chaplan SR, Wickenden AD, Lebsack AD, Breitenbucher JG. Rech JC, et al. Among authors: leenaerts je. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4781-4784. doi: 10.1016/j.bmcl.2016.08.029. Epub 2016 Aug 20. Bioorg Med Chem Lett. 2016. PMID: 27595421
Discovery of N-(4-[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer.
Rombouts FJR, Declercq L, Andrés JI, Bottelbergs A, Chen L, Iturrino L, Leenaerts JE, Mariën J, Song F, Wintmolders C, Wuyts S, Xia CA, Te Riele P, Bormans G, Vandenberghe R, Kolb H, Moechars D. Rombouts FJR, et al. Among authors: leenaerts je. J Med Chem. 2019 Mar 28;62(6):2974-2987. doi: 10.1021/acs.jmedchem.8b01759. Epub 2019 Mar 19. J Med Chem. 2019. PMID: 30810314
4-Phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives, a novel class of selective delta-opioid agonists.
Trabanco AA, Pullan S, Alonso JM, Alvarez RM, Andrés JI, Boeckx I, Fernández J, Gómez A, Iturrino L, Janssens FE, Leenaerts JE, De Lucas AI, Matesanz E, Meert T, Steckler T. Trabanco AA, et al. Among authors: leenaerts je. Bioorg Med Chem Lett. 2006 Jan 1;16(1):146-9. doi: 10.1016/j.bmcl.2005.09.025. Epub 2005 Oct 19. Bioorg Med Chem Lett. 2006. PMID: 16236510
4-Phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives as non-peptidic selective delta-opioid agonists with potential anxiolytic/antidepressant properties. Part 2.
Trabanco AA, Aerts N, Alvarez RM, Andrés JI, Boeckx I, Fernández J, Gómez A, Janssens FE, Leenaerts JE, De Lucas AI, Matesanz E, Steckler T, Pullan S. Trabanco AA, et al. Among authors: leenaerts je. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3860-3. doi: 10.1016/j.bmcl.2007.05.012. Epub 2007 May 10. Bioorg Med Chem Lett. 2007. PMID: 17512730
Discovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer's Disease.
Rombouts FJ, Andrés JI, Ariza M, Alonso JM, Austin N, Bottelbergs A, Chen L, Chupakhin V, Cleiren E, Fierens K, Fontana A, Langlois X, Leenaerts JE, Mariën J, Martínez Lamenca C, Salter R, Schmidt ME, Te Riele P, Wintmolders C, Trabanco AA, Zhang W, Macdonald G, Moechars D. Rombouts FJ, et al. Among authors: leenaerts je. J Med Chem. 2017 Feb 23;60(4):1272-1291. doi: 10.1021/acs.jmedchem.6b01173. Epub 2017 Feb 10. J Med Chem. 2017. PMID: 28106992
The Synthesis of Trifluoromethyl-sulfonimidamides from Sulfinamides.
Richards-Taylor CS, Martínez-Lamenca C, Leenaerts JE, Trabanco AA, Oehlrich D. Richards-Taylor CS, et al. Among authors: leenaerts je. J Org Chem. 2017 Sep 15;82(18):9898-9904. doi: 10.1021/acs.joc.7b01628. Epub 2017 Aug 30. J Org Chem. 2017. PMID: 28809121
Correction to Discovery of N-(4-[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer.
Rombouts FJR, Declercq L, Andrés JI, Bottelbergs A, Chen L, Iturrino L, Leenaerts JE, Mariën J, Song F, Wintmolders C, Wuyts S, Xia CA, Te Riele P, Bormans G, Vandenberghe R, Kolb H, Moechars D. Rombouts FJR, et al. Among authors: leenaerts je. J Med Chem. 2020 Feb 27;63(4):1775. doi: 10.1021/acs.jmedchem.0c00140. Epub 2020 Feb 18. J Med Chem. 2020. PMID: 32069047 No abstract available.