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Cathepsin G is broadly expressed in acute myeloid leukemia and is an effective immunotherapeutic target.
Alatrash G, Garber HR, Zhang M, Sukhumalchandra P, Qiu Y, Jakher H, Perakis AA, Becker L, Yoo SY, Dwyer KC, Coombes K, Talukder AH, John LSS, Senyukov V, Lee DA, Sergeeva A, He H, Ma Q, Armistead PM, Roszik J, Mittendorf EA, Molldrem JJ, Hawke D, Lizee G, Kornblau SM. Alatrash G, et al. Among authors: roszik j. Leukemia. 2017 Jan;31(1):234-237. doi: 10.1038/leu.2016.249. Epub 2016 Aug 30. Leukemia. 2017. PMID: 27573556 Free PMC article. No abstract available.
Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection.
Kumaresan PR, Manuri PR, Albert ND, Maiti S, Singh H, Mi T, Roszik J, Rabinovich B, Olivares S, Krishnamurthy J, Zhang L, Najjar AM, Huls MH, Lee DA, Champlin RE, Kontoyiannis DP, Cooper LJ. Kumaresan PR, et al. Among authors: roszik j. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10660-5. doi: 10.1073/pnas.1312789111. Epub 2014 Jul 7. Proc Natl Acad Sci U S A. 2014. PMID: 25002471 Free PMC article.
NLRC5/MHC class I transactivator is a target for immune evasion in cancer.
Yoshihama S, Roszik J, Downs I, Meissner TB, Vijayan S, Chapuy B, Sidiq T, Shipp MA, Lizee GA, Kobayashi KS. Yoshihama S, et al. Among authors: roszik j. Proc Natl Acad Sci U S A. 2016 May 24;113(21):5999-6004. doi: 10.1073/pnas.1602069113. Epub 2016 May 9. Proc Natl Acad Sci U S A. 2016. PMID: 27162338 Free PMC article.
Imaging of Sleeping Beauty-Modified CD19-Specific T Cells Expressing HSV1-Thymidine Kinase by Positron Emission Tomography.
Najjar AM, Manuri PR, Olivares S, Flores L 2nd, Mi T, Huls H, Shpall EJ, Champlin RE, Turkman N, Paolillo V, Roszik J, Rabinovich B, Lee DA, Alauddin M, Gelovani J, Cooper LJ. Najjar AM, et al. Among authors: roszik j. Mol Imaging Biol. 2016 Dec;18(6):838-848. doi: 10.1007/s11307-016-0971-8. Mol Imaging Biol. 2016. PMID: 27246312 Free PMC article.
Serine Proteases Enhance Immunogenic Antigen Presentation on Lung Cancer Cells.
Peters HL, Tripathi SC, Kerros C, Katayama H, Garber HR, St John LS, Federico L, Meraz IM, Roth JA, Sepesi B, Majidi M, Ruisaard K, Clise-Dwyer K, Roszik J, Gibbons DL, Heymach JV, Swisher SG, Bernatchez C, Alatrash G, Hanash S, Molldrem JJ. Peters HL, et al. Among authors: roszik j. Cancer Immunol Res. 2017 Apr;5(4):319-329. doi: 10.1158/2326-6066.CIR-16-0141. Epub 2017 Mar 2. Cancer Immunol Res. 2017. PMID: 28254787 Free PMC article.
4-1BB-Enhanced Expansion of CD8+ TIL from Triple-Negative Breast Cancer Unveils Mutation-Specific CD8+ T Cells.
Harao M, Forget MA, Roszik J, Gao H, Babiera GV, Krishnamurthy S, Chacon JA, Li S, Mittendorf EA, DeSnyder SM, Rockwood KF, Bernatchez C, Ueno NT, Radvanyi LG, Vence L, Haymaker C, Reuben JM. Harao M, et al. Among authors: roszik j. Cancer Immunol Res. 2017 Jun;5(6):439-445. doi: 10.1158/2326-6066.CIR-16-0364. Epub 2017 May 4. Cancer Immunol Res. 2017. PMID: 28473315 Free PMC article.
SLC45A2: A Melanoma Antigen with High Tumor Selectivity and Reduced Potential for Autoimmune Toxicity.
Park J, Talukder AH, Lim SA, Kim K, Pan K, Melendez B, Bradley SD, Jackson KR, Khalili JS, Wang J, Creasy C, Pan BF, Woodman SE, Bernatchez C, Hawke D, Hwu P, Lee KM, Roszik J, Lizée G, Yee C. Park J, et al. Among authors: roszik j. Cancer Immunol Res. 2017 Aug;5(8):618-629. doi: 10.1158/2326-6066.CIR-17-0051. Epub 2017 Jun 19. Cancer Immunol Res. 2017. PMID: 28630054 Free PMC article.
HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes.
Mbofung RM, McKenzie JA, Malu S, Zhang M, Peng W, Liu C, Kuiatse I, Tieu T, Williams L, Devi S, Ashkin E, Xu C, Huang L, Zhang M, Talukder AH, Tripathi SC, Khong H, Satani N, Muller FL, Roszik J, Heffernan T, Allison JP, Lizee G, Hanash SM, Proia D, Amaria R, Davis RE, Hwu P. Mbofung RM, et al. Among authors: roszik j. Nat Commun. 2017 Sep 6;8(1):451. doi: 10.1038/s41467-017-00449-z. Nat Commun. 2017. PMID: 28878208 Free PMC article.
Cathepsin G Is Expressed by Acute Lymphoblastic Leukemia and Is a Potential Immunotherapeutic Target.
Khan M, Carmona S, Sukhumalchandra P, Roszik J, Philips A, Perakis AA, Kerros C, Zhang M, Qiao N, John LSS, Zope M, Goldberg J, Qazilbash M, Jakher H, Clise-Dwyer K, Qiu Y, Mittendorf EA, Molldrem JJ, Kornblau SM, Alatrash G. Khan M, et al. Among authors: roszik j. Front Immunol. 2018 Jan 25;8:1975. doi: 10.3389/fimmu.2017.01975. eCollection 2017. Front Immunol. 2018. PMID: 29422892 Free PMC article.
The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression.
Huang L, Malu S, McKenzie JA, Andrews MC, Talukder AH, Tieu T, Karpinets T, Haymaker C, Forget MA, Williams LJ, Wang Z, Mbofung RM, Wang ZQ, Davis RE, Lo RS, Wargo JA, Davies MA, Bernatchez C, Heffernan T, Amaria RN, Korkut A, Peng W, Roszik J, Lizée G, Woodman SE, Hwu P. Huang L, et al. Among authors: roszik j. Clin Cancer Res. 2018 Jul 15;24(14):3366-3376. doi: 10.1158/1078-0432.CCR-17-2483. Epub 2018 Mar 1. Clin Cancer Res. 2018. PMID: 29496759 Free PMC article.
178 results